Proximal tubular injury in Chinese herbs nephropathy: monitoring by neutral endopeptidase enzymuria

Kidney International
J L NortierJ L Vanherweghem

Abstract

Neutral endopeptidase (NEP) is a 94 kDa ectoenzyme of the proximal tubule brush border, physiologically released into the urine with apical membrane fragments. As proximal tubular atrophy was a histological hallmark of Chinese herbs nephropathy (CHN), this study firstly determined renal excretion of NEP in healthy control subjects (N = 31), in patients with CHN (N = 26) and in women having consumed Chinese herbs and whose renal function was normal but running the risk of developing CHN (N = 27). Another patient group consisted of female patients with glomerular diseases (N = 12). At the same time, measurements of urinary microproteins (Clara cell protein, retinol binding protein, beta 2-microglobulin and alpha 1-microglobulin) were performed, as indicators of tubular dysfunction. Cell damage was estimated by the excretion of N-acetyl-beta-D-glucosaminidase (NAG). In the control group, the physiological NEP enzymuria was 43.1 micrograms/24 hr (geometric mean). In CHN patients, levels of urinary NEP were significantly decreased in those with moderate renal failure (26.7 micrograms/24 hr; N = 21; P < 0.05) and almost abolished in end-stage renal failure patients (4.35 micrograms/24 hr; N = 5; P < 0.05). In patients at risk as well...Continue Reading

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Citations

Mar 8, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yin-Tai HongChin-Shiang Chi
Aug 11, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joëlle L NortierPierre Ronco
Jan 20, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ascensión Martín-GranadoVíctor García-Nieto
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Jul 24, 2012·Toxicology and Applied Pharmacology·Zhenzhou JiangLuyong Zhang
Apr 18, 2008·Kidney International·Frédéric D DebelleJoëlle L Nortier
Oct 31, 2015·Néphrologie & thérapeutique·Joëlle NortierJean-Louis Vanherweghem
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Corinne Isnard BagnisJean Louis Vanherweghem
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