Proximal tumors are associated with greater mortality in colon cancer.

Journal of General Internal Medicine
Robert Wong

Abstract

Colon cancer is the third leading cause of death from cancer in the United States. Recent studies report on increasing proportions of proximal cancers. The etiology behind this epidemiological trend is unclear, and its implication on survival outcomes is unknown. Further analysis of the impact of anatomic site of disease among a large multiethnic population will help facilitate research and education to improve colon cancer screening and treatment. To investigate the association between proximal tumor location and survival in patients with colon cancer. A large retrospective cohort study in the US utilizing the Surveillance, Epidemiology, and End Results (SEER) cancer registry analyzed survival outcomes of patients with colon cancer. Multivariable logistic regression analyses investigated sex-specific, race/ethnicity-specific, and anatomic site-specific disparities in survival. Five-year survival outcomes from colon cancer. Our study demonstrated significant disparities in survival by sex, race/ethnicity, and anatomic site. Across all time periods and among most cohorts, patients with proximal cancers had significantly worse survival outcomes. When compared to distal cancers, patients with proximal cancers were 13% less likely ...Continue Reading

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Citations

Apr 11, 2013·European Journal of Human Genetics : EJHG·Giovanni CorsoFranco Roviello
Mar 21, 2012·Nutrition and Cancer·Zora DjuricIkuko Kato
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May 13, 2014·International Journal of Surgical Pathology·Brian D HayesCian Muldoon

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