PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics

Bioinformatics
Sherlyn JemimahM Michael Gromiha

Abstract

We have developed PROXiMATE, a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein-protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data. The database is freely available at http://www.iitm.ac.in/bioinfo/PROXiMATE/ . The website is implemented in Python, and supports recent versions of major browsers such as IE10, Firefox, Chrome and Opera. gromiha@iitm.ac.in. Supplementary data are available at Bioinformatics online.

References

Nov 25, 2003·Journal of Molecular Modeling·Ying GaoLuhua Lai
Dec 31, 2005·Nucleic Acids Research·M D Shaji Kumar, M Michael Gromiha
Jun 1, 2013·Nucleic Acids Research·Yves DehouckDimitri Gilis
Nov 28, 2013·Bioinformatics·Douglas E V PiresTom L Blundell
Sep 26, 2014·European Journal of Medicinal Chemistry·Andrew M Watkins, Paramjit S Arora
Oct 29, 2014·Nucleic Acids Research·UNKNOWN UniProt Consortium
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Oct 17, 2015·Protein Science : a Publication of the Protein Society·Sarah SirinAmy E Keating
Apr 15, 2016·International Journal of Molecular Sciences·Marharyta PetukhEmil Alexov
Nov 21, 2016·Current Opinion in Structural Biology·M Michael GromihaSherlyn Jemimah

❮ Previous
Next ❯

Citations

Mar 27, 2018·Protein Science : a Publication of the Protein Society·Connie Y WangBarry D Olafson
Apr 25, 2018·Database : the Journal of Biological Databases and Curation·Salman Sadullah UsmaniGajendra P S Raghava
Nov 20, 2018·Protein Engineering, Design & Selection : PEDS·Malka AkerMoshe Amitay
May 21, 2020·Nucleic Acids Research·Yoochan MyungDavid B Ascher
Oct 31, 2019·Bioinformatics·Yoochan MyungDouglas E V Pires
Feb 27, 2020·Current Topics in Medicinal Chemistry·Olivia SlaterMaria Kontoyianni
Apr 11, 2020·International Journal of Molecular Sciences·Swagata PahariEmil Alexov
May 23, 2019·Nucleic Acids Research·Carlos H M RodriguesDavid B Ascher
Mar 7, 2019·Current Topics in Medicinal Chemistry·Vishnupriya KanakavetiM Michael Gromiha
Aug 10, 2020·Computers in Biology and Medicine·Sherlyn Jemimah, M Michael Gromiha
Apr 25, 2021·Nucleic Acids Research·Carlos H M RodriguesDavid B Ascher
Jul 18, 2021·Journal of Molecular Biology·Jiahui ChenGuo-Wei Wei
Jun 16, 2021·Journal of Bioinformatics and Computational Biology·Wajid Arshad AbbasiSaiqa Andleeb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Quantum Bio-informatics V : Proceedings of the Quantum Bio-informatics 2011, Tokyo University of Science, Japan, 7-12 March 2011
Hui Li, Chunmei Liu
Methods in Molecular Biology
M Michael Gromiha, A Sarai
© 2022 Meta ULC. All rights reserved