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Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1

Molecular Cell

Feb 8, 2005

Christopher R VakocGerd A Blobel

Abstract

Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation of chromatin loops. Here, we examined the mechanism for DNA looping at the beta-globin locus. By using chromosome conformation capture (3C), we show that the h...read more

Mentioned in this Paper

Pathologic Cytolysis
Gata1 protein, mouse
Embryo
Zinc Fingers
Real-Time Polymerase Chain Reaction
RNA Polymerase II
Chromatin Loop
GATA1 protein, human
Deoxyribonuclease I
Krueppel-Like Factor 1
207
Paper Details
References
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Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1

Molecular Cell

Feb 8, 2005

Christopher R VakocGerd A Blobel

PMID: 15694345

DOI: 10.1016/j.molcel.2004.12.028

Abstract

Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation of chromatin loops. Here, we examined the mechanism for DNA looping at the beta-globin locus. By using chromosome conformation capture (3C), we show that the h...read more

Mentioned in this Paper

Pathologic Cytolysis
Gata1 protein, mouse
Embryo
Zinc Fingers
Real-Time Polymerase Chain Reaction
RNA Polymerase II
Chromatin Loop
GATA1 protein, human
Deoxyribonuclease I
Krueppel-Like Factor 1
207

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Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Molecular Cell

Looping and interaction between hypersensitive sites in the active beta-globin locus

Molecular CellDecember 31, 2002
Bas TolhuisWouter de Laat
Paper Details
References
  • References31
  • Citations245
1234
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