Proximity effects in chromosome aberration induction: Dependence on radiation quality, cell type and dose

DNA Repair
John James Tello CajiaoF Ballarini

Abstract

It is widely accepted that, in chromosome-aberration induction, the (mis-)rejoining probability of two chromosome fragments depends on their initial distance, r. However, several aspects of these "proximity effects" need to be clarified, also considering that they can vary with radiation quality, cell type and dose. A previous work performed by the BIANCA (BIophysical ANalysis of Cell death and chromosome Aberrations) biophysical model has suggested that, in human lymphocytes and fibroblasts exposed to low-LET radiation, an exponential function of the form exp(-r/r0), which is consistent with free-end (confined) diffusion, describes proximity effects better than a Gaussian function. Herein, the investigation was extended to intermediate- and high-LET. Since the r0 values (0.8 μm for lymphocytes and 0.7 μm for fibroblasts) were taken from the low-LET study, the results were obtained by adjusting only one model parameter, i.e. the yield of "Cluster Lesions" (CLs), where a CL was defined as a critical DNA damage producing two independent chromosome fragments. In lymphocytes, the exponential model allowed reproducing both dose-response curves for different aberrations (dicentrics, centric rings and excess acentrics), and values of ...Continue Reading

References

Apr 1, 1986·Mutation Research·J Pohl-RülingB C Das
Nov 1, 1994·International Journal of Radiation Biology·A A EdwardsH Nikjoo
Jan 1, 1997·International Journal of Radiation Biology·R K SachsD J Brenner
Aug 4, 1998·International Journal of Radiation Biology·M Bauchinger, E Schmid
Jun 29, 1999·Radiation and Environmental Biophysics·A OttolenghiM Merzagora
Jan 2, 2001·International Journal of Radiation Biology·W DengJ N Lucas
Oct 20, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A OttolenghiM Biaggi
Oct 19, 2002·Radiation Research·W R HolleyA Chatterjee
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F Ballarini, A Ottolenghi
Aug 17, 2004·Radiation and Environmental Biophysics·Francesca Ballarini, Andrea Ottolenghi
Sep 29, 2005·Radiation Research·Francesca Ballarini, Andrea Ottolenghi
May 1, 2007·Journal of Molecular Biology·Sergey V RazinYegor S Vassetzky
Aug 7, 2007·PLoS Computational Biology·Sylvain V CostesMary Helen Barcellos-Hoff
Oct 27, 2010·Journal of Nucleic Acids·Francesca Ballarini
Apr 12, 2012·Radiation Research·Artem L PonomarevFrancis A Cucinotta
Aug 16, 2013·Radiation Research·Francesca BallariniNicoletta Protti
Mar 25, 2014·Radiation and Environmental Biophysics·Francesca BallariniNicoletta Protti
May 10, 2015·Radiation and Environmental Biophysics·M P CaranteF Ballarini
Apr 20, 2016·Frontiers in Oncology·Mario Pietro Carante, Francesca Ballarini
Sep 2, 2017·DNA Repair·John James Tello CajiaoFrancesca Ballarini

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Citations

Nov 23, 2019·Radiation and Environmental Biophysics·Konrad CzerskiEvgeny Krasavin
Jun 5, 2020·International Journal of Molecular Sciences·Mario P CaranteFrancesca Ballarini
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Spyridon A KalospyrosAlexandros G Georgakilas

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