PrP(Sc) is associated with B cells in the blood of scrapie-infected sheep

Virology
J C EdwardsLinda A Terry

Abstract

Recently, we reported that PrP(Sc), a surrogate marker for prion disease, is associated with the cellular fraction of blood from scrapie-infected sheep using a ligand-based immunoassay. In the study reported here, we found that a subset of peripheral blood mononuclear cells is most likely to sequester PrP(Sc) during both the preclinical phase of disease and at clinical end point. These cells had a cell surface phenotype of MHC class II DQ(+), surface immunoglobulin(+), CD11b(+), CD11c(+), CD21(+/)(-), which is consistent with a subpopulation of B cells. What role these cells play in the pathogenesis of scrapie is unclear, but they may contribute to the trafficking of prions to the spleen during early pathogenesis of the disease. Furthermore, tests for preclinical diagnostics could be further improved by targeting these cells.

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Citations

Apr 23, 2013·BMC Veterinary Research·Rohana P DassanayakeKatherine I O'Rourke
Jan 27, 2012·The Journal of General Virology·Rohana P DassanayakeKatherine I O'Rourke
Dec 31, 2014·Journal of Veterinary Science·Rohana P DassanayakeKatherine I O'Rourke
Nov 25, 2011·BMC Veterinary Research·Rohana P DassanayakeKatherine I O'Rourke
Mar 8, 2018·Artificial Organs·Ina Laura PieperCatherine A Thornton
Oct 3, 2018·Analytical Chemistry·Elisabeth MaritschneggRobert Zeillinger

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