PRRDB: a comprehensive database of pattern-recognition receptors and their ligands.

BMC Genomics
Sneh Lata, G P S Raghava

Abstract

Recently in a number of studies, it has been demonstrated that the innate immune system doesn't merely acts as the first line of defense but provides critical signals for the development of specific adaptive immune response. Innate immune system employs a set of receptors called pattern recognition receptors (PRRs) that recognize evolutionarily conserved patterns from pathogens called pathogen associated molecular patterns (PAMPs). In order to assist scientific community, a database PRRDB has been developed that provides extensive information about pattern recognition receptors and their ligands. The current version of database contains around 500 patterns recognizing receptors from 77 distinct organisms ranging from insects to human. This includes 177 Toll-like receptors, 124 are Scavenger receptors and 67 are Nucleotide Binding Site-Leucine repeats rich receptors. The database also provides information about 266 ligands that includes carbohydrates, proteins, nucleic acids, glycolipids, glycoproteins, lipopeptides. A number of web tools have been integrated in PRRDB in order to provide following services: i) searching on any field; ii) database browsing; and iii) BLAST search against the pattern-recognition receptors. PRRDB al...Continue Reading

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Citations

Oct 13, 2009·Nucleic Acids Research·Hifzur Rahman AnsariG P S Raghava
Jul 11, 2009·BMC Genomics·Mamoon RashidGajendra P S Raghava
Apr 18, 2012·PloS One·Abhijit AithalGrish C Varshney
Sep 27, 2008·Nanomedicine·Willi Jahnen-Dechent, Ulrich Simon
Aug 1, 2008·Expert Opinion on Drug Discovery·Kiyoko F Aoki-Kinoshita
Dec 6, 2011·Biochemical and Biophysical Research Communications·Qing-Bin GaoJia He
Jul 28, 2015·Scientific Reports·Gandharva NagpalGajendra P S Raghava
Mar 27, 2016·Briefings in Bioinformatics·Sandeep Kumar DhandaGajendra P S Raghava
Aug 28, 2014·Briefings in Bioinformatics·Shipra GuptaDeepti D Deobagkar
Dec 1, 2009·Probiotics and Antimicrobial Proteins·A LindeT Melgarejo
Jul 11, 2020·Expert Review of Vaccines·Kimia KardaniAli Namvar
Jun 30, 2019·Database : the Journal of Biological Databases and Curation·Dilraj KaurGajendra P S Raghava
Feb 23, 2020·Frontiers in Immunology·Dilraj KaurGajendra P S Raghava
Jun 23, 2021·Molecular Diagnosis & Therapy·Dilraj KaurGajendra Pal Singh Raghava

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Software Mentioned

PERL
CGIperl
PostgresSQL
Solaris
Apache
BLAST
PostgreSQL
Pgperl
PDRB
PRRDB

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