PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are involved in vasculogenesis during rat embryonic pituitary development

Cell and Tissue Research
Masashi HiguchiYukio Kato

Abstract

We have recently shown that cells positive for the paired-related homeobox transcription factors PRRX1 and PRRX2 occur in the rat pituitary, and that they are derived from two different origins: pituitary-derived cells positive for stem cell marker SOX2 and extra-pituitary-derived cells negative for SOX2. In this study, we have further characterized the PRRX1- and PRRX2-positive cells that originate from extra-pituitary cells. Immunohistochemical analyses were performed with specific antibodies against PRRX1 and PRRX2 in order to clarify their roles in pituitary vasculogenesis. PRRX1- and PRRX2-positive cells were found in Atwell's recess and at the periphery of the pituitary on embryonic day 15.5 (E15.5). Several PRRX1-positive cells then invaded the anterior lobe, together with a few PRRX2-positive cells, on E16.5. Some PRRX1-positive cells were also positive for mesenchymal stem cell marker NESTIN. Moreover, some PRRX1/NESTIN double-positive cells showed characteristics of vascular endothelial cells with an Isolectin-B4-binding capacity. PRRX1 co-localized with vascular smooth muscle cell/pericyte marker α-smooth muscle actin in the deep area of Atwell's recess. We confirmed the presence of PRRX2/NESTIN double-positive cells...Continue Reading

References

Mar 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O SkalliL Orci
Jul 1, 1985·The Journal of Cell Biology·I M Herman, P A D'Amore
May 1, 1981·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·S DaikokuK Yoshinaga
Jul 24, 1998·Trends in Genetics : TIG·D E Watkins-Chow, S A Camper
Apr 25, 2000·Biochemical and Biophysical Research Communications·E Hunziker, M Stein
Sep 24, 2004·Current Opinion in Genetics & Development·Xiaoyan Zhu, Michael G Rosenfeld
Sep 26, 2006·Journal of Dental Research·J M MitchellM J Kern
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Josette M Douville, Jeffrey T Wigle
Jul 7, 2007·Physiological Reviews·Xiaoyan ZhuMichael G Rosenfeld
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Teddy FauquierIain C A F Robinson
May 7, 2009·Stem Cells·Jianghai ChenHugo Vankelecom
May 16, 2009·Biochemical and Biophysical Research Communications·Saishu YoshidaYukio Kato
Sep 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anamaria BalicMina Mina
Nov 18, 2009·General and Comparative Endocrinology·Hugo Vankelecom, Lies Gremeaux
Aug 13, 2010·Nature·Simón Méndez-FerrerPaul S Frenette
Dec 15, 2010·The European Journal of Neuroscience·Hugo Vankelecom
Sep 13, 2013·Cell and Tissue Research·Hideji YakoYukio Kato
Apr 29, 2014·Cell and Tissue Research·Masashi HiguchiYukio Kato
Jun 3, 2014·The Journal of Reproduction and Development·Saishu YoshidaYukio Kato
Jun 3, 2014·The Journal of Reproduction and Development·Hiroki UeharuYukio Kato

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Citations

Sep 22, 2016·Molecular and Cellular Endocrinology·Leonard Y M CheungMaría Inés Pérez-Millán
May 15, 2018·Biology of Reproduction·Whitney Edwards, Lori T Raetzman
Nov 15, 2020·Science Advances·Andrew B CaldwellShankar Subramaniam
Sep 23, 2021·Cell and Tissue Research·Yukio KatoTakako Kato

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