PMID: 9653113Jul 8, 1998Paper

PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway

Proceedings of the National Academy of Sciences of the United States of America
Thomas PotuschakA Bachmair

Abstract

Mutants in the PRT1 gene of Arabidopsis thaliana are impaired in the degradation of a normally short-lived intracellular protein that contains a destabilizing N-terminal residue. Proteins bearing such residues are the substrates of an ubiquitin-dependent proteolytic system called the N-end rule pathway. The chromosomal position of PRT1 was determined, and the PRT1 gene was isolated by map-based cloning. The 45-kDa PRT1 protein contains two RING finger domains and one ZZ domain. No other proteins in databases match these characteristics of PRT1. There is, however, a weak similarity to Rad18p of Saccharomyces cerevisiae. The RING finger domains have been found in a number of other proteins that are involved in ubiquitin conjugation, consistent with the proposed role of PRT1 in the plant N-end rule pathway.

References

Oct 1, 1992·The Plant Cell·J GiraudatH M Goodman
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R J DohmenA Varshavsky
Nov 1, 1991·The Plant Journal : for Cell and Molecular Biology·I HwangB Lemieux
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 24, 1989·Cell·A Bachmair, A Varshavsky
Nov 1, 1995·The Plant Journal : for Cell and Molecular Biology·F CreusotA Durr
Jan 1, 1996·Trends in Biochemical Sciences·C P PontingS J Winder
Oct 1, 1996·Plant Molecular Biology·R D Vierstra
Jan 1, 1996·Annual Review of Genetics·M Hochstrasser
Jan 1, 1997·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·A Varshavsky
Feb 21, 1998·Nucleic Acids Research·D A BensonB F Ouellette
Dec 31, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A L Haas, T J Siepmann
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A BachmairJ Schell
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D ValvekensM Van Lijsebettens

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Citations

Sep 15, 2004·Plant Cell Reports·Claus Schwechheimer, Katja Schwager
Oct 9, 2001·Trends in Plant Science·A BachmairF Eisenhaber
Oct 6, 2000·Current Opinion in Plant Biology·J Callis, R D Vierstra
Oct 22, 2011·Nature Reviews. Molecular Cell Biology·Shashikanth M SriramYong Tae Kwon
Nov 26, 1999·The Plant Journal : for Cell and Molecular Biology·P W Bates, R D Vierstra
May 25, 2002·The Plant Journal : for Cell and Molecular Biology·Christian S HardtkeXing Wang Deng
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tara J HolmanMichael J Holdsworth
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Emmanuelle GracietFrank Wellmer
Nov 15, 2008·The Journal of Biological Chemistry·Takafumi TasakiYong Tae Kwon
Jan 13, 2005·Plant Physiology·Sophia L StoneJudy Callis
Feb 10, 1999·Plant Physiology·D HondredR D Vierstra
Oct 9, 2002·The Plant Cell·Erik Jan KlokElizabeth S Dennis
Oct 31, 2003·Molecular and Cellular Biology·Yong Tae KwonAlexander Varshavsky
Sep 21, 2004·Annual Review of Plant Biology·Jan Smalle, Richard D Vierstra
Jun 6, 2009·Annual Review of Biochemistry·Raymond J Deshaies, Claudio A P Joazeiro
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·A Di ColaL M Roberts
Apr 25, 2012·Annual Review of Biochemistry·Takafumi TasakiYong Tae Kwon
May 31, 2014·Trends in Cell Biology·Daniel J GibbsMichael J Holdsworth
Apr 4, 2007·Seminars in Immunology·J M SchartnerC M Seroogy
Feb 20, 2007·Trends in Cell Biology·Axel MogkBernd Bukau
Dec 17, 2009·The Plant Journal : for Cell and Molecular Biology·Emmanuelle GracietFrank Wellmer
Apr 7, 2006·Current Opinion in Plant Biology·Linda L Walling
Oct 17, 2014·The Arabidopsis Book·Judy Callis
Feb 9, 2000·Current Biology : CB·P S Freemont
Jun 27, 2014·Frontiers in Genetics·Medha Raina, Michael Ibba
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Min Kyung KimHyun Kyu Song
Apr 18, 2009·Molecular Aspects of Medicine·Tobias JungTilman Grune
May 14, 2016·Scientific Reports·Rémi de MarchiEmmanuelle Graciet
Feb 16, 2017·Genetics and Molecular Biology·Tatiana DomitrovicMaite F S Vaslin

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