Pru p 3-Glycodendropeptides Based on Mannoses Promote Changes in the Immunological Properties of Dendritic and T-Cells from LTP-Allergic Patients

Molecular Nutrition & Food Research
Francisca PalomaresCristobalina Mayorga

Abstract

Glycodendropeptides (GDPs) functionalized with mannose can enhance allergen interaction with dendritic cells (DCs) via C-type lectin receptors (CLRs), modulating the immune response. They can present multiple peptides and have potential applications for diagnosis and treatment of food allergy (FA). The immune response induced by GDPs with mannose and Pru p 3 peptides (mono/tetravalent) with ester (D1 ManPrup3/D4 ManPrup3) or ether linkers (D1 Man-O- Prup3/D4 Man-O- Prup3) in lipid-transfer-protein-allergic patients and tolerant controls is analyzed. The immunological response induced by GDPs is studied by assessing monocyte-derived-DC maturation, lymphocyte proliferation, cytokine production, and basophil response by flow cytometry. Dn ManPrup3 was recognized by DCs via CLRs inducing DC maturation in all subjects. However, CCR7 expression is significantly upregulated in allergic patients compared to tolerant controls. These changes correlate with lymphocyte proliferation and specific production of Th2/Th1 cytokines in allergic patients. Moreover, D1 ManPrup3 does not induce basophil activation. Dn ManPrup3 induces changes in DC maturation and lymphocyte proliferation, indicating specific recognition via CLRs. Prup3-GDPs are rec...Continue Reading

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Citations

Feb 10, 2021·Allergy·Cristobalina MayorgaMaria Isabel Montañez
Mar 9, 2021·Frontiers in Immunology·Charlotte CastenmillerYvette van Kooyk
May 31, 2021·Trends in Immunology·B C Keumatio DoungstopY van Kooyk
Jun 3, 2021·Foods·Cristobalina MayorgaFrancisca Gómez
Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen
Jan 29, 2020·Molecular Pharmaceutics·Sara BenedéEva Batanero
Nov 12, 2021·ACS Chemical Biology·Jorge Losada MéndezJavier Rojo

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