Prucalopride for constipation

Expert Opinion on Pharmacotherapy
M Camilleri, Annemie Deiteren

Abstract

Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients. A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT(4), R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly. Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation. Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.

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Apr 10, 2021·Biochemical and Biophysical Research Communications·Yun ShiYan-Qin Shen
Apr 13, 2021·Expert Review of Clinical Pharmacology·Daiane Franco TeixeiraMairim Russo Serafini

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