Prucalopride for the treatment of constipation: a view from 2015 and beyond

Expert Review of Gastroenterology & Hepatology
Gabrio BassottiMassimo Bellini

Abstract

Prucalopride is a prokinetic drug, that has been commercially available in recent years for the treatment of chronically constipated patients. In this update of a previous 2016 article, we reviewed the more recent data supporting its role in the treatment of constipation and constipation-associated conditions. Areas covered: We carried out an extensive literature review on the effects of prucalopride for the years 2012-2018 by means of scientific databases and manual research. More evidence was found on its possible therapeutic role in conditions in which constipation plays a role as an associated symptom, such as opioid-induced constipation, constipation-predominant irritable bowel syndrome, post-operative ileus, colonic diverticular disease, drug-related constipation, and chronic intestinal pseudo-obstruction. Expert opinion: Based on the added literature evidence, we feel that prucalopride is an effective, although expensive, drug for the treatment of primary and secondary forms of constipation, and of other clinical conditions associated with constipation.

References

Jan 1, 1992·Memórias do Instituto Oswaldo Cruz·M F Abdel Wahab, G Esmat
Sep 1, 1994·Digestive Diseases and Sciences·G BassottiW E Whitehead
Mar 17, 2000·Scandinavian Journal of Gastroenterology·R De GiorgioC Sternini
Apr 17, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G BassottiM Tonini
Dec 10, 2003·Archives of Surgery·Gabrio BassottiAntonio Morelli
Apr 30, 2010·Digestive Diseases and Sciences·Cornelius E J SlootsMartine De Pauw
Oct 1, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningI J Cook
Jan 4, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C J Smart, A N Ramesh
May 11, 2012·International Journal of Colorectal Disease·Bruno AnnibaleRosario Cuomo
Oct 11, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J TackR Kerstens
Nov 2, 2014·United European Gastroenterology Journal·Rosario CuomoBruno Annibale
May 1, 2015·Frontiers in Pharmacology·Mark J C NuijtenLieven Annemans
Dec 10, 2015·Expert Review of Gastroenterology & Hepatology·Gabrio BassottiMassimo Bellini
Jan 26, 2016·Journal of Clinical Gastroenterology·Antonio Tursi
Apr 6, 2016·Gastroenterología y hepatología·Jordi SerraFermín Mearin Manrique
May 5, 2016·Gastroenterology·Fermín MearinRobin Spiller
Jun 9, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P B MinerB Mellgard
Aug 4, 2016·BMJ Open Gastroenterology·Irene SonuJerry D Gardner
Sep 27, 2016·Journal of Visceral Surgery·A VenaraG Meurette
Jan 17, 2017·Journal of Gastroenterology and Hepatology·Carolina MalageladaFernando Azpiroz
Nov 18, 2017·Therapeutic Advances in Gastroenterology·Anam Omer, Eamonn M M Quigley
Dec 1, 2017·World Journal of Gastrointestinal Endoscopy·Vito Domenico CorletoEmilio di Giulio
Dec 20, 2017·Journal of Clinical Psychopharmacology·Amitkumar ChouguleP S V N Sharma
Jan 29, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Judy NeeAnthony Lembo
Feb 28, 2018·Digestive Diseases and Sciences·Edda BattagliaGabrio Bassotti
Apr 7, 2018·Nature Reviews. Gastroenterology & Hepatology·Jutta KellerUNKNOWN International Working Group for Disorders of Gastrointestinal Motility and Function
May 12, 2018·The Australian and New Zealand Journal of Psychiatry·Naveen ThomasChristos Pantelis
Jul 5, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G Dinning

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Citations

Sep 17, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Rachel M Gwynne, Joel C Bornstein
Oct 3, 2019·Expert Review of Clinical Pharmacology·Gabrio BassottiMassimo Bellini
Dec 11, 2019·Minerva gastroenterologica e dietologica·Imke MasuyJan Tack
Dec 5, 2019·Clinical Pharmacology in Drug Development·Ziye ZhouXiuhua Zhang
Mar 8, 2021·Best Practice & Research. Clinical Rheumatology·Timothy KanieckiZsuzsanna H McMahan

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