Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation.

Oxidative Medicine and Cellular Longevity
Hyeong-U SonSang-Han Lee

Abstract

The Prunus mume seed is a by-product of the food industry, and we studied its potential as a food biomaterial, particularly for nutraceutical and inner beauty products. Alternative animal tests showed that an extract of P. mume ripened seed (PmRS) was not toxic on the skin. PmRS exhibited protective effects against ultraviolet- (UV-) induced skin aging in mice, confirmed by phenotypic indications, including increased collagen levels and decreased skin thickness. Compared with the UV-saline group, the UV-PmRS group showed increased levels of silent mating type information regulation 2 homolog 1 (SIRT1) and collagen and decreased matrix metalloproteinase- (MMP-) 1 expression. The protective effect of PmRS treatment against UVB-mediated cell viability was observed in vitro without any cytotoxicity, and PmRS prevented UVB-induced reactive oxygen species generation in HaCaT cells. PmRS downregulated MMP-1 and MMP-13 compared with the UVB-irradiated group. However, mRNA expressions of tissue inhibitor of metalloproteinase-1 and SIRT1 were upregulated by PmRS treatment. MMP-1 and SIRT1 treated with PmRS were decreased and increased, respectively, at the protein level. Moreover, PmRS treatment reduced c-Jun N-terminal kinase and p38 ph...Continue Reading

References

Oct 1, 1979·The Gerontologist·E Palmore
Nov 1, 1994·The British Journal of Dermatology·Y TakemaG Imokawa
Sep 5, 2002·Ageing Research Reviews·Laure Rittié, Gary J Fisher
Nov 20, 2002·Archives of Dermatology·Gary J FisherJohn J Voorhees
Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Mina YaarBarbara A Gilchrest
Feb 13, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·R. TaoA. Sugiura
Sep 27, 2003·Dermatologic Therapy·Robert A Norman
Nov 26, 2003·Journal of the American Academy of Dermatology·Ethan G RigelDarrell S Rigel
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Nov 15, 2006·Current Drug Targets·Johannes Trapp, Manfred Jung
Dec 1, 2007·Clinical Interventions in Aging·Siddharth MukherjeeGünther Weindl
Feb 1, 1982·International Journal of Cosmetic Science·T F Cash, D W Cash
Aug 14, 2009·The Journal of Investigative Dermatology. Symposium Proceedings·Taihao QuanGary J Fisher
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Aug 9, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ali Abdel-RahmanNigel J Walker
Oct 11, 2011·Cell Biology International·Yang Baohua, Li Li
Oct 12, 2011·Journal of the Science of Food and Agriculture·Fazilah AriffinNurul Huda
Nov 26, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pulok K MukherjeeBirendra K Sarkar
Feb 5, 2013·Archives of Dermatological Research·Melissa SerravalloNeil I Brody
Jul 23, 2013·Asian Pacific Journal of Tropical Medicine·Long-Quan Shi, Cai-Lian Ruan
Feb 4, 2014·Bioorganic & Medicinal Chemistry Letters·Xi-Tao YanYoung-Ho Kim
Feb 18, 2014·Journal of Natural Medicines·Katsuyoshi FujimotoHisashi Matsuda
Apr 10, 2014·The Journal of Investigative Dermatology·Angela TewariAntony R Young
Feb 11, 2015·Microscopy Research and Technique·Kyung Sook KimMin Kyung Shin
Feb 26, 2016·Pharmaceutical Biology·Min Woo LeeSe Chan Kang
Mar 2, 2016·Experimental Gerontology·Xiu-Fen WangHui-Fang Zeng
Jan 7, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Umar MuzafferN Rajendra Prasad

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