Prurigo as a clinical prodrome to adult T-cell leukaemia/lymphoma

The British Journal of Dermatology
M SetoyamaT Kanzaki

Abstract

We report a case of adult T-cell leukaemia/lymphoma (ATLL) with prurigo as a prodromal skin manifestation. The patient was a 52-year-old woman with a 2-year history of a fluctuating skin condition consisting of pruritic papules and pigmentation on her lower legs and right buttock. Prurigo was diagnosed at her first visit in October 1995, and she was found to be seropositive for human T-cell lymphotropic virus type 1 (HTLV-1). Two years later, the skin lesions had spread over the patient's forearms and dorsa of the hands, and abnormal lymphoid cells had appeared in her peripheral blood. Southern blot analysis revealed monoclonal integration of HTLV-1 provirus in the peripheral blood, but not in a skin lesion. Based on these results, a diagnosis of overt ATLL of the smouldering type was made. The findings in this case indicate that in healthy HTLV-1 seropositive carriers, prurigo requires careful follow-up as a cutaneous prodrome of ATLL.

References

Sep 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·R A Rosychuk
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May 1, 1996·The Australasian Journal of Dermatology·T KanzakiY Katahira
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Citations

Oct 5, 2010·International Journal of Dermatology·Achiléa L Bittencourt, Maria de Fátima Paim de Oliveira
Jan 1, 1998·Hematology·F Ravandi-KashaniF J Giles
Nov 7, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·A C do ValleJ de Ameida Dobbin
Oct 3, 2003·International Journal of Dermatology·Fernanda C PereiraMarcello Menta S Nico
Oct 12, 2013·International Journal of Dermatology·Lorena DantasPaulo Machado
Feb 18, 2005·Revista Da Sociedade Brasileira De Medicina Tropical·Vandack NobreUNKNOWN Grupo Interdisciplinar de Pesquisas em HTLV-1/2
Jun 19, 2003·The American Journal of Tropical Medicine and Hygiene·Denise Utsch GonçalvesUNKNOWN Interdisciplinary HTLV-1/2 Research Group
Jun 22, 2018·Case Reports in Dermatology·Shireen DumontLaurence Toutous Trellu

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