Prurigo Pigmentosa: Literature Review

American Journal of Clinical Dermatology
Bryce D BeutlerRobert A Lee

Abstract

Prurigo pigmentosa, also referred to as Nagashima's disease, is a rare inflammatory skin condition of unknown etiology. It typically presents as pruritic erythematous papules, papulovesicles, and vesicles appearing in a reticular pattern on the back, chest, or neck. The histological features of prurigo pigmentosa vary according to the stage of the disease. Early-stage disease is characterized by a superficial perivascular infiltrate of neutrophils; spongiosis and necrotic keratinocytes commonly appear in later stages. The etiology of prurigo pigmentosa has yet to be determined. Oral minocycline is usually the first-line therapy for prurigo pigmentosa. However, doxycycline, macrolide antibiotics, and/or dapsone (diaminodiphenyl sulfone) may be indicated for some patients. We describe the key features of prurigo pigmentosa, including the epidemiology, clinical and histologic presentation, differential diagnosis, postulated pathogenesis, and treatment options for this condition.

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Citations

Apr 13, 2018·Pediatric Dermatology·Isa AnSedat Akdeniz
Aug 15, 2018·International Journal of Dermatology·Antonina V KalmykovaOksana N Sulaieva
Apr 28, 2018·International Journal of Dermatology·Michela LaiLaura Atzori
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Nov 20, 2019·The Australasian Journal of Dermatology·Chunxia Zhao, Yang Peng
May 21, 2020·The American Journal of Dermatopathology·Gabriel E MolinaJiaDe Yu
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Jan 30, 2020·The American Journal of Dermatopathology·Johanna Pirrone, Almut Böer-Auer
Jan 27, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Sarah Schäfer, Ferdinand Toberer
Dec 9, 2020·The American Journal of Dermatopathology·Eduardo Rozas-MuñozJuan Francisco Mir-Bonafé
Jul 10, 2019·Open Life Sciences·Xinjun Wang, Chenchen Xu
Nov 14, 2020·The American Journal of Medicine·Mouna Ben HamoudaMohamed Denguezli
Jul 25, 2021·European Journal of Clinical Nutrition·H Y Sun, D F Sebaratnam
Jul 11, 2021·The Medical Journal of Australia·Blake P Mumford, Anita Lasocki
Nov 27, 2021·International Journal of Dermatology·Shaghayegh ShahrigharahkoshanKevin Pehr

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