Pruritic and nociceptive sensations and dysesthesias from a spicule of cowhage.

Journal of Neurophysiology
Robert H LaMotteD Zelterman

Abstract

Although the trichomes (spicules) of a pod of cowhage (Mucuna pruriens) are known to evoke a histamine-independent itch that is mediated by a cysteine protease, little is known of the itch and accompanying nociceptive sensations evoked by a single spicule and the enhanced itch and pain that can occur in the surrounding skin. The tip of a single spicule applied to the forearm of 45 subjects typically evoked 1) itch accompanied by nociceptive sensations (NS) of pricking/stinging and, to a lesser extent, burning, and 2) one or more areas of cutaneous dysesthesia characterized by hyperknesis (enhanced itch to pricking) with or without alloknesis (itch to stroking) and/or hyperalgesia (enhanced pricking pain). Itch could occur in the absence of NS or one or more dysesthesias but very rarely the reverse. The peak magnitude of sensation was positively correlated for itch and NS and increased (exhibited spatial summation) as the number of spicules was increased within a spatial extent of 6 cm but not 1 cm. The areas of dysesthesia did not exhibit spatial summation. We conclude that itch evoked by a punctate chemical stimulus can co-exist with NS and cutaneous dysesthesias as may occur in clinical pruritus. However, cowhage itch was not...Continue Reading

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Citations

Dec 25, 2012·Nature Neuroscience·Liang HanXinzhong Dong
Jun 23, 2012·Journal of Neurophysiology·Steve DavidsonGlenn J Giesler
Nov 3, 2010·The Journal of Clinical Investigation·Qiufu Ma
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May 20, 2016·Experimental Dermatology·Emil A HoeckLars Arendt-Nielsen
Oct 10, 2020·Nature Communications·Sihan ChenZhou-Feng Chen

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