Pruritus: Progress toward Pathogenesis and Treatment

BioMed Research International
Jing SongJianqiao Zhong

Abstract

Pruritus, the most common cutaneous symptom, is widely seen in many skin complaints. It is an uncomfortable feeling on the skin and sometimes impairs patients' quality of life. At present, the specific mechanism of pruritus still remains unclear. Antihistamines, which are usually used to relieve pruritus, ineffectively work in some patients with itching. Recent evidence has suggested that, apart from histamine, many mediators and signaling pathways are involved in the pathogenesis of pruritus. Various therapeutic options for itching correspondingly have been developed. In this review, we summarize the updated pathogenesis and therapeutic strategies for pruritus.

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Mar 22, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·Y B Lee, W S Lee
Jul 16, 2020·International Journal of Molecular Sciences·Shirin KahremanyGuy Cohen
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Oct 14, 2021·Acta Dermato-venereologica·Dominika Kwiatkowska, Adam Reich

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