pS2 (TFF1) expression in prostate carcinoma: correlation with steroid receptor status

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Asmaa Gaber AbdouSultan Mohamed Sultan

Abstract

pS2 or TFF1 is a member of the trefoil factor family, which is distributed throughout the gastrointestinal tract in both normal and diseased tissues. It is also considered to be one of the major estrogen-regulated proteins and an indicator of estrogen receptor (ER) functionality. pS2 has previously been investigated in benign and malignant prostate lesions with little information about its relationship to steroid receptor status. Our purpose was to correlate pS2 expression with steroid receptor status (ER alpha and progesterone receptor (PR)) and other pathologic variables in prostate carcinoma. 15 benign prostate hyperplasia (BPH) and 47 prostate carcinoma cases were investigated by means of immunohistochemistry for pS2, ER and PR expression. 80% of BPH showed pS2 cytoplasmic immunoreactivity in hyperplastic acini and about half of these cases also exhibited nuclear staining decorating basal or both basal and luminal nuclei. pS2 was highly expressed in prostate carcinoma (91.4%) with both cytoplasmic and nuclear patterns of staining. The latter pattern was significantly associated with carcinoma having a low Gleason score (p=0.02). pS2 lacked any significant correlation with steroid receptor status, stage or grade. Univariate ...Continue Reading

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Citations

Apr 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Daniel R RadiloffXiao-Fan Wang
Oct 29, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Asmaa G AbdouMarwa Serag El-Dien
Dec 1, 2017·Cancer Research·Natalia Martín-MartínArkaitz Carracedo

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