PMID: 7538187May 1, 1995Paper

PSA-detected prostate cancer: contrasts with palpable disease

Journal of Surgical Oncology
G J Matthews, J A Fracchia

Abstract

The clinical and pathologic characteristics of 100 consecutive men with clinically localized prostate cancer and staged by radical prostatectomy were reviewed. Men with impalpable prostate-specific antigen (PSA) detected cancers (T1c) were contrasted against men with palpable disease (TB). Lesions were clinically staged as T1c in 53 men and TB in 47 men. Mean serum PSA for men with T1c cancers was 11.8 +/- 0.7 ng/dL (normal: 0 > 4) and 14.1 +/- 1.7 ng/dL for men with TB disease. Histologic evaluation revealed a mean Gleason's sum of 6.4 +/- 0.2 (scale: 2 > 10) for T1c lesions and 6.6 +/- 0.2 for men with TB cancers (P = NS). DNA content was diploid in 67% of T1c cancers and 62% of TB lesions (P = NS). An overall 43% clinical staging error was observed. Extraprostatic extension was demonstrated in 36% of T1c cancers and 51% TB lesions (P = NS). PSA-detected cancers were indistinguishable from palpable lesions by all measures evaluated. Prostate cancers detected in asymptomatic men by an elevated PSA should be considered biologically significant lesions.

References

Mar 1, 1990·The Journal of Urology·W J Catalona, S W Bigg
Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Nov 1, 1994·The Journal of Urology·D S Smith, W J Catalona
Aug 25, 1993·JAMA : the Journal of the American Medical Association·W J CatalonaJ W Basler

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Citations

Nov 1, 1996·Journal of Clinical Ultrasound : JCU·G J MatthewsJ A Fracehia
Jan 4, 2012·Histopathology·Liang ChengDaniel M Berney
Dec 22, 1998·Acta Oncologica·J B Rietbergen, F H Schröder
Sep 13, 2005·BJU International·Sandra A ArmatysLiang Cheng

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