Psammoma bodies in cervicovaginal cytology specimens: a clinicopathological analysis of 31 cases

Gynecologic Oncology
Joseph MisdrajiDebra A Bell

Abstract

Psammoma bodies in cervicovaginal cytology specimens are associated with malignant and benign conditions. Few studies have evaluated which features distinguish patients with underlying malignancy from those with benign conditions. Pathology files were searched for cervicovaginal specimens having psammoma bodies. The cytology specimen was assessed for the background, glandular atypia, squamous atypia, and presence of non-psammomatous calcifications. Clinical data was obtained from chart review. Nineteen women (mean age 42.7 years) had benign outcomes. None had signs or symptoms suggesting malignancy. None had highly atypical or malignant appearing glandular cells. Twelve women had malignant neoplasms (mean age 56 years), including 6 with recurrent disease. Four women without prior malignancy had worrisome signs including bleeding or mass. All six women with prior malignancy had signs of recurrent disease. All specimens contained highly atypical or malignant glandular cells. The only cytologic feature predictive of outcome was the presence of highly atypical glandular cells in the specimen (P = 0.001), but these cells may be few. Women with underlying malignancy were older than those with benign outcome (P = 0.014) and more likel...Continue Reading

References

Oct 5, 2001·Gynecologic Oncology·J L NicklinD Cominos
Jan 11, 2003·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R D Athavale, K V Chia
Jun 26, 2003·American Journal of Obstetrics and Gynecology·Howard G MuntzChristina Isacson

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Citations

Jun 19, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·J H F Smith
Jul 17, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·T UeharaM Shozu
Nov 2, 2019·Journal of Cutaneous Pathology·Hellen B de Pontes SantosRoseana de Almeida Freitas
Dec 27, 2011·Journal of the Chinese Medical Association : JCMA·Shih-Chao Kang, Shinn-Jang Hwang

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