Pseudo progression in heterogeneity of right-sided metastatic colon carcinoma during nivolumab therapy: A case report

Medicine
Jing WangXindan Kang

Abstract

Pseudo progression is a noted phenomenon of immune checkpoint inhibitors therapy, which has been defined as a response after an initial enlargement of the tumor followed by tumor reduction. In July 2017, the Food and Drug Administration granted accelerated approval of nivolumab for the treatment of metastatic colorectal cancer patients whose tumor harbors deficient mismatch repair. We present a patient who received nivolumab for heterogeneity of right-sided metastatic colon carcinoma. The patient was treated with nivolumab combined with chemotherapy. The computed tomography showed mass lesion in the left lobe of liver remained stable while metastasis tumors under envelop of liver were exacerbated after 6 cycles of nivolumab combined with chemotherapy, and later regressed. The status of mismatch repair in primary tumor and metastatic liver carcinoma is contradictory but using nivolumab demonstrated encouraging efficacy. This is the first case of pseudo progression undergoing immunotherapy for heterogeneity of right-sided metastatic colon carcinoma.

References

Jan 24, 2009·British Journal of Cancer·M KoopmanJ H J M van Krieken
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephan E BaldusHelmut E Gabbert
Feb 4, 2012·Nature Reviews. Drug Discovery·Lorenzo GalluzziGuido Kroemer
May 25, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H SorbyeB Glimelius
Mar 4, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J GoldsteinM J Overman
Aug 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine VenderboschMiriam Koopman
Jun 24, 2015·International Journal of Colorectal Disease·Thierry LandreGaetan Des Guetz
Aug 12, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria L Chiou, Mauricio Burotto
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Oct 12, 2017·The New England Journal of Medicine·Steven LemeryRichard Pazdur
Nov 29, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M TazdaitC Caramella
Feb 24, 2018·Future Oncology·Amir Mehrvarz SarshekehScott Kopetz
Oct 23, 2018·Oncotarget·Sofía Del CarmenMaría Del Mar Abad
Nov 24, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daichi FujimotoToyohiro Hirai

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Citations

Nov 24, 2020·OncoTargets and Therapy·Xianzhe YuJianguo Li
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jiangang SunYongshun Gao

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