Pseudo-template molecularly imprinted polymer for selective screening of trace beta-lactam antibiotics in river and tap water

Journal of Chromatography. a
Junfa YinHailin Wang

Abstract

To assess the potential risks associated with the environmental exposure of beta-lactam antibiotics (BLAs), the monitoring of the occurrence, distribution, and fate of these emerging contaminants in the environment is required. Herein, we demonstrate a molecularly imprinted solid-phase extraction (MISPE) method for selective and reliable screening of trace BLAs in river and tap water. By developing a low-temperature photopolymerization, highly selective molecularly imprinted polymers (MIPs) for five BLAs (penicillin G, amoxicillin, ampicillin, nafcillin and mezlocillin) were synthesized. Nafcillin was chosen as a pseudo template to make the MIP sorbent (Nafc-MIP), which was used in pseudo-template MISPE for preconcentration of the other four BLAs from river and tap water. The application of pseudo-template MISPE overcomes the template bleeding, which significantly elevates the sample background and restricts the application of MIP for detection of the target BLA below 2 microg/L. The average recoveries of BLAs are in the range of 60-90% when Nafc-MIP was adopted as the selective MISPE sorbent. The developed method was validated, and applied to the screening of trace beta-lactam antibiotics in river and tap water. The linearity ...Continue Reading

Citations

Feb 22, 2014·Environmental Science and Pollution Research International·Haidong ZhouYong Zhan
Oct 5, 2014·Environmental Science and Pollution Research International·Dan-Lian HuangChao Huang
Mar 19, 2015·Journal of Analytical Methods in Chemistry·Mónica Díaz-BaoPatricia Regal
Dec 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Hsin-Pin HoMaw-Rong Lee
Apr 5, 2014·Journal of Molecular Recognition : JMR·Michael J WhitcombeIan A Nicholls
May 18, 2020·Environmental Monitoring and Assessment·Cansu Ilke KuruSinan Akgöl
Dec 22, 2017·Environmental Science and Pollution Research International·Paula S PintoRochel M Lago
Jan 1, 2011·Analytical Methods : Advancing Methods and Applications·Junfa YinHailin Wang

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