Pseudoanaplastic tumors of bone

Skeletal Radiology
Won-Jong Bahk, Joseph M Mirra

Abstract

To discuss the concept of pseudoanaplastic tumors of bone, which pathologically show hyperchromatism and marked pleomorphism with quite enlarged, pleomorphic nuclei, but with no to extremely rare, typical mitoses, and to propose guidelines for their diagnosis. From a database of 4,262 bone tumors covering from 1971 to 2001, 15 cases of pseudoanaplastic bone tumors (0.35% of total) were retrieved for clinical, radiographic and pathologic review. Postoperative follow-up after surgical treatment was at least 3 years and a maximum of 7 years. There were eight male and seven female patients. Their ages ranged from 10 to 64 years with average of 29.7 years. Pathologic diagnoses of pseudoanaplastic variants of benign bone tumors included: osteoblastoma (4 cases), giant cell tumor (4 cases), chondromyxoid fibroma (3 cases), fibrous dysplasia (2 cases), fibrous cortical defect (1 case) and aneurysmal bone cyst (1 case). Radiography of all cases showed features of a benign bone lesion. Six cases, one case each of osteoblastoma, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, giant cell tumor and osteoblastoma, were initially misdiagnosed as osteosarcoma. The remaining cases were referred for a second opinion to rule out s...Continue Reading

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Citations

Jul 6, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akihiko YoshidaHitoshi Tsuda
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Edward C HsiaoRobert A Nissenson
Mar 1, 2012·Surgical Pathology Clinics·Adriana L Gonzalez, Justin M M Cates
Mar 30, 2016·Skeletal Radiology·Judy SarungbamMeera Hameed
Oct 29, 2015·Head and Neck Pathology·Shruti KashikarPaul Freedman
Aug 13, 2011·Acta Radiologica·Hyun-Soo KimIn-Young Ok
Feb 8, 2007·Archives of Pathology & Laboratory Medicine·Andrea T Deyrup, Anthony G Montag

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