Pseudodysplastic epithelial artefacts associated with oral mucosa CO2 laser excision: an assessment of margin status

International Journal of Oral and Maxillofacial Surgery
J SeoaneP Varela-Centelles

Abstract

Using a CO(2) laser beam for biopsy is compromised by thermal cytological artefacts that could be critical when assessing dysplastic changes, as they may simulate cytological atypia. This study examined wounds caused by CO(2) laser, evaluating their size and features, utilizing 25 Sprage rats randomly allocated to five groups: four glossectomized using a CO(2) laser at 3, 6, 9 and 12 W and a control group treated with a conventional scalpel. Samples were prepared in 4 microm sections, stained, and studied double-blind by two pathologists. The artefacts identified included cellular and nuclear polymorphism, nuclear hyperchromatism and loss of intercellular adherence; they were mainly located in the basal and suprabasal layers of the oral epithelium. Number of artefacts per specimen did not differ between experimental groups. The width of epithelial damage adjacent to the laser incisions revealed 298.7+/-150.7 microm of damaged tissue (range 100-750 microm), with no differences between low (3 W) and high wattages (6, 9 and 12 W) (X(i)-X(j)=41.6; 95% CI=-125.1 to 208.4). No changes were observed in the control group. CO(2) laser (3-12 W) generates epithelial damage that can simulate light dysplasia with atypias mainly affecting ba...Continue Reading

References

Mar 1, 1978·The Journal of the American Dental Association·M L Bernstein
Apr 1, 1977·Southern Medical Journal·D R Klein
Jul 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·K OhtakeT Nakajima
Nov 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·M A PogrelT E Daniels
Mar 1, 1990·Oral Surgery, Oral Medicine, and Oral Pathology·M A PogrelL S Hansen
Jun 1, 1989·Archives of Otolaryngology--head & Neck Surgery·W R PanjeM Karnell
Feb 1, 1986·International Journal of Oral and Maxillofacial Surgery·H H HorchH E Schaefer
Jan 1, 1987·Lasers in Surgery and Medicine·R M Pick, B C Pecaro
Feb 1, 1987·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·G FicarraL S Hansen
Mar 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J E MargaroneC D Vaughan
Aug 1, 1985·Journal of Oral Pathology·A Wright, M Shear
Apr 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·W J GarehimeD Green
Nov 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·B C Pecaro, W J Garehime
Aug 1, 1995·The British Journal of Oral & Maxillofacial Surgery·I MouleG H Irvine
Mar 1, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J LiboonD J Terris
Jan 1, 1997·Lasers in Surgery and Medicine·M KautzkyP Schenk
Jun 1, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L R Eversole
Dec 12, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·R A Convissar
Jun 16, 1999·The Laryngoscope·M L SchoelchS Silverman
Aug 18, 2000·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J KusukawaT Kameyama
Jul 6, 2001·The Journal of Pathology·S Warnakulasuriya
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M WeijersI van der Waal
Jul 10, 2002·International Journal of Oral and Maxillofacial Surgery·P J Thomson, J Wylie
Dec 11, 2002·Clinical Otolaryngology and Allied Sciences·J SeoaneA De La Cruz
Nov 26, 2008·Photomedicine and Laser Surgery·Kousuke MatsumotoTakahide Komoro

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Citations

Aug 9, 2011·Photomedicine and Laser Surgery·Pía López-JornetFrancisco Gómez-García
Feb 8, 2014·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Fawaz M MakkiS Mark Taylor
May 1, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Valerie G A SuterMichael M Bornstein
Feb 22, 2012·Oral and Maxillofacial Surgery Clinics of North America·Joshua E Lubek, Lewis Clayman
Oct 7, 2011·The British Journal of Oral & Maxillofacial Surgery·A González-MosqueraP Varela-Centelles

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