Pseudoendogenous origin of prednisolone in pigs from the food chain

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Francesco ArioliLuca Chiesa

Abstract

The debate about the origin of prednisolone in animal organisms has lasted for 5 years. Bovine species have been the most studied, but studies on humans and horses are also present in the literature. Even if prednisolone in pigs does not yet represent a problem for control agencies, interest has recently increased with regard to this species. To date, there has been just a single study in the literature about this topic, performed on 10 sows treated with prednisolone or a synthetic analogue of adrenocorticotropic hormone. We therefore initiated a study on 80 pigs, a number considered representative in relation to the expected frequency (prevalence) of prednisolone detection in urine collected at slaughter. Prednisolone was detected in urine both at the farm and at the slaughterhouse, with a concentration and frequency higher at slaughter. The presence of prednisolone was also studied in the adrenal glands, where the corticosteroids are produced in response to stress, and it was detected in 89% of the samples. These results, together with the similar behaviours of prednisolone and cortisol, i.e. a mutual rise in the two corticosteroids in urine collected at the slaughterhouse and the correlation between the concentrations of the...Continue Reading

References

Jan 5, 2002·Journal of Chromatography. a·K ShimadaT Higashi
Jan 5, 2002·Journal of Chromatography. a·O Nozaki
May 4, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Michael BredehöftWilhelm Schänzer
Nov 28, 2012·Steroids·Marco FidaniFrancesco Arioli
Jan 8, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Radmila PavlovicLuca Chiesa
Apr 10, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Luigi BertocchiFrancesco Arioli
Jan 8, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Eva de RijkeLeendert A van Ginkel

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Methods Mentioned

BETA
urine collection

Software Mentioned

GraphPad InStat
GraphPad

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