Pseudoephedrine/ephedrine shows potent anti-inflammatory activity against TNF-α-mediated acute liver failure induced by lipopolysaccharide/D-galactosamine

European Journal of Pharmacology
Zhongping WuXuejun Yang

Abstract

The anti-inflammatory effects of pseudoephedrine/ephedrine were investigated using the experimental model of lipopolysaccharide (LPS)-induced acute liver failure in D-galactosamine (D-GalN)-sensitised male rats in order to elucidate effects other than sympathomimetic effects. Rats were intraperitoneally injected with D-GalN (400 mg/kg) and LPS (40 μg/kg) to induce acute liver failure. The treatment groups were then intraperitoneally administered pseudoephedrine/ephedrine at 0 h and 4 h after induction and the activation induced by treatment with pseudoephedrine and/or LPS on the primary Kupffer cells (KCs) was monitored. Compared with controls induced by GalN/LPS alone, pseudoephedrine dramatically reduced the infiltration of inflammatory cells and bile ductular hyperplasia and hepatic necrosis observed in liver sections. It inhibited both hepatocellular apoptosis and the expression of monocyte chemotactic protein-1. It lowered the production of tumour necrosis factor-α (TNF-α) in the beginning of acute liver failure induced by D-GalN/LPS. Correspondingly, levels of alanine aminotransferase (ALT), total bilirubin (TBIL) and malondialdehyde were attenuated. Ephedrine demonstrated all these identical protective effects as well. I...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·V GoossensW Fiers
Jun 11, 1999·Journal of Sports Sciences·R Eston, D Peters
Aug 17, 1999·Biochemical Pharmacology·S S Vansal, D R Feller
Apr 17, 2002·Annals of Internal Medicine·Joya T FavreauTse-Ling Fong
Apr 26, 2003·Cell Biology International·V ValatasE A Kouroumalis
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yong-Han PaikDavid A Brenner
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guilhermo RezendeCyrille Féray
Nov 14, 2006·British Journal of Pharmacology·J T LilesP J Kadowitz
Dec 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G C ActisM Rizzetto
Dec 6, 2008·World Journal of Gastroenterology : WJG·Lily DaraJoseph Kartaik Lim
Sep 4, 2010·Journal of Hepatology·Maria L OllerosIrene Garcia
Mar 3, 2011·The Journal of the Royal College of Physicians of Edinburgh·M R Lee
Apr 6, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean-Charles Duclos-ValléeDidier Samuel
Apr 14, 2011·Transplantation Proceedings·M L Schilsky
Jun 3, 2011·Immunopharmacology and Immunotoxicology·Bernd L FiebichLuz M Bellido

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Citations

Nov 3, 2015·Asian Pacific Journal of Tropical Medicine·Rong-Zhen ZhangDe-Wen Mao
May 27, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marek SaracynZofia Wańkowicz
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Khaoula ElhadefLotfi Mellouli
Feb 13, 2016·International Journal of Molecular Medicine·Xueqiang JiangDeying Tian
Feb 14, 2018·International Journal of Molecular Medicine·Sang Mi ParkSang Chan Kim
Jun 2, 2020·Infection & chemotherapy·Hyoung Shik Shin
Aug 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marykate KillileaAntony M Wheatley
Oct 11, 2020·Luminescence : the Journal of Biological and Chemical Luminescence·Yuhui ZhangJidong Yang
Dec 15, 2020·Human & Experimental Toxicology·Chanhong ShiJianwei Li
May 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Shuhan ZhouWenliang Lv
Jun 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shi WuJinhao Zeng
Aug 25, 2020·Acta Pharmaceutica Sinica. B·Liqiang NiHongzhuan Chen

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