Pseudogenes in ribonuclease evolution: a source of new biomacromolecular function?

FEBS Letters
N Trabesinger-RuefS A Benner

Abstract

Bovine seminal ribonuclease (RNase) diverged from pancreatic RNase after a gene duplication ca. 35 million years ago. Members of the seminal RNase gene family evidently remained as unexpressed pseudogene for much of its evolutionary history. Between 5 and 10 million years ago, however, after the divergence of kudu but before the divergence of ox, evidence suggests that the pseudogene was repaired and expressed. Intriguingly, detailed analysis of the sequences suggests that the repair may have involved gene conversion, transfer of information from the pancreatic gene to the RNase pseudogene. Further, the ratio of non-silent to silent substitutions suggests that the pancreatic RNases are divergently evolving under functional constraints, the seminal RNase pseudogenes are diverging under no functional constraints, while the genes expressed in the seminal plasma are evolving extremely rapidly in their amino acid sequences, as if to fulfil a new physiological role.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M W AllardM R Tennant
Apr 1, 1991·Seminars in Thrombosis and Hemostasis·F Markwardt
Oct 1, 1989·Trends in Biochemical Sciences·S A Benner, R K Allemann
Jan 1, 1989·Annual Review of Biochemistry·L J Wysocki, M L Gefter
Jan 1, 1988·Progress in Biophysics and Molecular Biology·J J BeintemaA Carsana
Jan 1, 1987·Methods in Enzymology·K B Mullis, F A Faloona
Jan 25, 1969·Nature·E A Barnard
Oct 1, 1984·Transplantation·J Klein
Jan 1, 1984·Journal of Molecular Evolution·T H Jukes, M Kimura
Jul 16, 1981·Nature·W H LiM Nei
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·C R MarshallR A Raff
Mar 3, 1994·Biochimica Et Biophysica Acta·J P VosB M Gadella
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C EikenboomP H Reitsma
Feb 26, 1993·Science·C K Yoon

❮ Previous
Next ❯

Citations

Jun 27, 2002·Journal of Molecular Biology·Paul M Harrison, Mark Gerstein
Jun 11, 2002·Journal of Molecular Biology·K Fukami-KobayashiS A Benner
Jun 7, 2003·Advances in Enzyme Regulation·Steven A Benner
Oct 8, 1998·Advances in Enzyme Regulation·S A BennerD Schreiber
May 10, 2001·Biochimica Et Biophysica Acta·W ZhaoJ J Beintema
Jun 5, 1998·Gene·H J BreukelmanJ J Beintema
Jul 20, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J Matousek
Jul 15, 2000·Animal Genetics·J G HickfordA P Escayg
Dec 3, 1999·European Journal of Biochemistry·G D'alessio
Jul 17, 2001·European Journal of Biochemistry·H J BreukelmanJ J Beintema
Feb 28, 2002·Nucleic Acids Research·Jianzhi ZhangHelene F Rosenberg
Jul 12, 2007·Genome Research·Daria V BabushokHaig H Kazazian
Jul 15, 1997·European Journal of Biochemistry·D J StrydomB L Vallee
Nov 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jianming ZhangManyuan Long
Aug 23, 2008·Science·Gregory A HorwitzArnold J Berk
Feb 29, 2000·FEBS Letters·A J MighellA F Markham
Oct 17, 2015·The Plant Journal : for Cell and Molecular Biology·Susanne SchillingGünter Theißen
Nov 18, 2003·Annual Review of Genetics·Evgeniy S Balakirev, Francisco J Ayala
Apr 18, 2001·Genome Biology·D A LiberlesS A Benner
May 27, 2005·Current Biology : CB·Quinn M Mitrovich, Philip Anderson
Feb 3, 2007·Molecular Biology and Evolution·Slim O SassiSteven A Benner
Mar 31, 2000·Molecular Biology and Evolution·G C RobinJ G Oakeshott
Sep 18, 1998·Andrologia·E Töpfer-PetersenJ J Calvete
Sep 14, 2006·Molecular Diversity·Kimberly D Dyer, Helene F Rosenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.