Pseudohypercalcemia in an elderly patient with multiple myeloma: report of a case and review of literature.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
J D SchwabJ L Shaker

Abstract

Hypercalcemia, a common complication of multiple myeloma, is primarily caused by increased bone resorption. The increase in total calcium is usually associated with an increase in the ionized calcium (Ca(I)), and the hypercalcemia is frequently symptomatic. Rarely, pseudohypercalcemia in multiple myeloma is caused by binding of calcium to the abnormal immunoglobulin. In this setting, the Ca(I) is normal. We describe a 90-year-old woman with an IgA-k myeloma who had substantial increases in the total calcium but normal levels of Ca(I). Clinicians should recognize this unusual phenomenon to avoid unnecessary and potentially toxic therapy.

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Citations

Apr 10, 2010·British Journal of Haematology·Jeremy T S Sargent, Owen P Smith
Jan 30, 2021·Case Reports in Endocrinology·Paula JeffsNadyeschka Rivera-Santana

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