Pseudohypericin and hyperforin in Hypericum perforatum from Northern Turkey: variation among populations, plant parts and phenological stages

Journal of Integrative Plant Biology
Cüneyt CirakLiudas Ivanauskas

Abstract

Hypericum perforatum is a perennial medicinal plant known as "St. John's wort" in Western Europe and has been used in the treatment of several diseases for centuries. In the present study, morphologic, phenologic and population variability in pseudohypericin and hyperforin concentrations among H. perforatum populations from Northern Turkey was investigated for the first time. The aerial parts of H. perforatum plants representing a total of 30 individuals were collected at full flowering from 10 sites of Northern Turkey to search the regional variation in the secondary metabolite concentrations. For morphologic and phenologic sampling, plants from one site were gathered in five phenological stages: vegetative, floral budding, full flowering, fresh fruiting and mature fruiting. The plant materials were air-dried at room temperature and subsequently assayed for chemical concentrations by high performance liquid chromatography. Secondary metabolite concentrations ranged from traces to 2.94 mg/g dry weight (DW) for pseudohypericin and traces -6.29 mg/g DW for hyperforin. The differences in the secondary metabolite concentrations among populations of H. perforatum were found to be significant. The populations varied greatly in hyperf...Continue Reading

References

Sep 11, 2001·Drug Development and Industrial Pharmacy·M C BergonziF F Vincieri
Dec 18, 2001·Journal of Ethnopharmacology·C C Sánchez-MateoR M Rabanal
Mar 26, 2004·Biochemical Pharmacology·Christian Feisst, Oliver Werz
Sep 3, 2004·Cancer Research·Massimo DonàSpiridione Garbisa
Jan 28, 2006·Life Sciences·Miguel A MedinaAna R Quesada

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Citations

Mar 8, 2017·The Journal of Pharmacy and Pharmacology·Anastasia AgapoudaDezső Csupor
Jan 25, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Nebojša KladarBiljana Božin
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ran LiIan T Baldwin

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