Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.

Phytochemistry
Kimberly D P HammerDiane F Birt

Abstract

Hypericum perforatum (Hp) has been used medicinally to treat a variety of conditions including mild-to-moderate depression. Recently, several anti-inflammatory activities of Hp have been reported. An ethanol extract of Hp was fractionated with the guidance of an anti-inflammatory bioassay (lipopolysaccharide (LPS)-induced prostaglandin E2 production (PGE2)), and four constituents were identified. When combined together at concentrations detected in the Hp fraction to make a 4 component system, these constituents (0.1microM chlorogenic acid (compound 1), 0.08microM amentoflavone (compound 2), 0.07microM quercetin (compound 3), and 0.03microM pseudohypericin (compound 4)) explained the majority of the activity of the fraction when activated by light, but only partially explained the activity of this Hp fraction in dark conditions. One of the constituents, light-activated pseudohypericin, was necessary, but not sufficient to explain the reduction in LPS-induced PGE2 of the 4 component system. The Hp fraction and the 4 component system inhibited lipoxygenase and cytosolic phospholipase A2, two enzymes in the PGE2-mediated inflammatory response. The 4 component system inhibited the production of the pro-inflammatory cytokine tumor n...Continue Reading

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Citations

Sep 2, 2011·Analytical Chemistry·Berin A BoughtonUte Roessner
May 27, 2011·Journal of Medicinal Food·José A A SantosValber da Silva Frutuoso
Mar 23, 2011·Journal of Ethnopharmacology·P Capelari-OliveiraD A Saúde-Guimarães
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Kimberly D P Hammer, Diane F Birt
Nov 13, 2009·Pharmaceutical Biology·Diane F BirtJason P Price

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