Abstract
Hypericum perforatum (Hp) has been used medicinally to treat a variety of conditions including mild-to-moderate depression. Recently, several anti-inflammatory activities of Hp have been reported. An ethanol extract of Hp was fractionated with the guidance of an anti-inflammatory bioassay (lipopolysaccharide (LPS)-induced prostaglandin E2 production (PGE2)), and four constituents were identified. When combined together at concentrations detected in the Hp fraction to make a 4 component system, these constituents (0.1microM chlorogenic acid (compound 1), 0.08microM amentoflavone (compound 2), 0.07microM quercetin (compound 3), and 0.03microM pseudohypericin (compound 4)) explained the majority of the activity of the fraction when activated by light, but only partially explained the activity of this Hp fraction in dark conditions. One of the constituents, light-activated pseudohypericin, was necessary, but not sufficient to explain the reduction in LPS-induced PGE2 of the 4 component system. The Hp fraction and the 4 component system inhibited lipoxygenase and cytosolic phospholipase A2, two enzymes in the PGE2-mediated inflammatory response. The 4 component system inhibited the production of the pro-inflammatory cytokine tumor n...Continue Reading
References
Sep 26, 1992·Biochemical and Biophysical Research Communications·M G O'SullivanC E McCall
Feb 1, 1991·Photochemistry and Photobiology·S Carpenter, G A Kraus
Nov 1, 1991·The Journal of Experimental Medicine·R de Waal MalefytJ E de Vries
Oct 1, 1993·Inflammation·M Lindahl, C Tagesson
Aug 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·C TournaireE Oliveros
Dec 27, 1996·The Journal of Biological Chemistry·W L SmithD L DeWitt
Sep 1, 1996·The Journal of Experimental Medicine·J P PortanovaP C Isakson
Jun 10, 1998·Planta medica·V ButterweckA Nahrstedt
Nov 24, 1999·Journal of Neuropathology and Experimental Neurology·L MinghettiV H Perry
Oct 29, 2000·Annals of the Rheumatic Diseases·B B Aggarwal
May 23, 2001·Archives of Biochemistry and Biophysics·K MurotaJ Terao
Sep 5, 2001·Carcinogenesis·J PrzybyszewskiD F Birt
Feb 14, 2002·Planta medica·Guido Jürgenliemk, Adolf Nahrstedt
May 15, 2002·Life Sciences·Anna Rita BiliaFranco F Vincieri
Jul 27, 2002·Planta medica·Michael Nöldner, Karl Schötz
Oct 25, 2002·The Journal of Pharmacy and Pharmacology·Giuseppina Mattace RasoRosaria Meli
Nov 30, 2002·Phytotherapy Research : PTR·Maria CouladisAnargyros Loukis
Apr 5, 2003·Planta medica·V ButterweckA Nahrstedt
Aug 16, 2003·Advances in Experimental Medicine and Biology·Kenneth T Calamia
Jan 22, 2004·Planta medica·Guido JuergenliemkAdolf Nahrstedt
Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·David S SenchinaMarian L Kohut
Mar 23, 2006·Cancer Chemotherapy and Pharmacology·Mohammad Al-FayezAndreas J Gescher
Mar 24, 2006·Journal of Chromatography. a·Felicia B WilliamsJames Girard
Apr 13, 2006·Journal of Agricultural and Food Chemistry·Laura A SchmittDiane F Birt
Jul 25, 2006·Journal of Photochemistry and Photobiology. B, Biology·Laura A SchmittDiane F Birt
Aug 29, 2006·Biochemical Pharmacology·Mònica ComaladaAntonio Zarzuelo
Mar 24, 2007·Journal of Natural Products·Shixin DengJarakae C Jensen
Aug 19, 2007·Journal of Agricultural and Food Chemistry·Kimberly D P HammerDiane F Birt
Citations
Sep 2, 2011·Analytical Chemistry·Berin A BoughtonUte Roessner
Nov 19, 2009·Journal of Agricultural and Food Chemistry·Nan HuangDiane F Birt
May 27, 2011·Journal of Medicinal Food·José A A SantosValber da Silva Frutuoso
Jan 17, 2012·Phytochemistry·Nan HuangDiane F Birt
Aug 23, 2011·Phytochemistry·Nan HuangDiane F Birt
Oct 5, 2010·Neuroscience·X YangJ C-M Lee
Mar 23, 2010·Phytochemistry·Kimberly D P HammerDiane F Birt
Jun 30, 2015·Cellular and Molecular Neurobiology·Zahra KiasalariMehrdad Roghani
Mar 23, 2011·Journal of Ethnopharmacology·P Capelari-OliveiraD A Saúde-Guimarães
Dec 19, 2013·Critical Reviews in Food Science and Nutrition·Kimberly D P Hammer, Diane F Birt
May 17, 2017·The Journal of Pharmacy and Pharmacology·Fuat UslusoyTolga Taha Sönmez
Nov 13, 2009·Pharmaceutical Biology·Diane F BirtJason P Price