Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus. An extremely well-differentiated, nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: a report of 10 cases of a distinctive clinicopathologic entity

The American Journal of Surgical Pathology
Antonio L CubillaRobert H Young

Abstract

We present 10 cases of well-differentiated, squamous cell carcinoma of the penis with pseudohyperplastic features. At presentation, the median age was 69 years. Seven of the tumors were multicentric, and the majority preferentially involved the foreskin inner mucosal surface. Grossly the tumors were typically flat or slightly elevated, white and granular, and measured approximately 2 cm. Characteristic histologic features included keratinizing nests of squamous cells with minimal atypia surrounded by a reactive fibrous stroma. In biopsies or individual areas of resected specimens, the differential diagnosis with pseudoepitheliomatous hyperplasia was difficult but when samples of adequate size were available, obvious evidence of infiltration was present. The adjacent squamous epithelium typically showed changes that are known to be associated with squamous cell carcinoma ranging from squamous hyperplasia to low-grade, and in a few cases high-grade, squamous intraepithelial lesions. Well-developed lichen sclerosus was seen in all cases. Patients were treated by circumcision or partial penectomy. With the exception of 1 patient who developed a glans recurrence 2 years after initial circumcision, follow-up after the initial surgica...Continue Reading

References

May 1, 1992·Plastic and Reconstructive Surgery·G V CampusL Bosincu
May 1, 1987·The Journal of Dermatologic Surgery and Oncology·P WeberL Garland
Jan 1, 1987·The Journal of Dermatologic Surgery and Oncology·P J WeberH Menn
Aug 15, 1980·American Journal of Obstetrics and Gynecology·J BuscemaJ D Woodruff
Mar 1, 1995·Journal of the American Academy of Dermatology·J J MeffertR E Grimwood
Aug 1, 1993·The American Journal of Surgical Pathology·A L CubillaM Riveros
Sep 1, 1993·Journal of the American Academy of Dermatology·H B PrideW B Tyler
Dec 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P CarliB Giannotti
Jun 1, 1999·BJU International·C J Cold, J R Taylor
Nov 26, 1999·Journal of the American Academy of Dermatology·M R NascaG Micali
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·G von Krogh, S Horenblas
Oct 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R E EmersonL Cheng

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Citations

Sep 20, 2011·Der Urologe. Ausg. A·C HoferU Treiber
Jul 9, 2008·World Journal of Urology·M C G BleekerC J L M Meijer
Sep 4, 2008·World Journal of Urology·Antonio L Cubilla
Mar 5, 2011·Current Oncology Reports·Gustavo Cardoso GuimarãesFernando Augusto Soares
Jan 2, 2007·The American Journal of Surgical Pathology·José E BarretoAntonio L Cubilla
May 31, 2012·Seminars in Diagnostic Pathology·Alcides ChauxAntonio L Cubilla
Nov 3, 2009·Urologic Oncology·Roberto SalvioniNicola Nicolai
Jun 16, 2009·The Journal of Urology·Gustavo Cardoso GuimarãesAntonio L Cubilla
Oct 16, 2007·The Journal of Urology·Jennifer M PuglieseAndrew C Peterson
Jun 17, 2015·Current Problems in Cancer·Michelle ChristodoulidouAsif Muneer
Jan 22, 2005·European Urology·F AlgabaUNKNOWN Uropathology Working Group
Mar 7, 2006·The Journal of Urology·G BarbagliM Lazzeri
Sep 26, 2006·The Journal of Infection·Robert S Van Howe
Feb 21, 2006·Journal of the American Academy of Dermatology·Giuseppe MicaliRobert A Schwartz
Feb 23, 2018·Der Urologe. Ausg. A·A Erbersdobler
Jun 15, 2005·Clinical and Experimental Dermatology·E Calonje
Aug 27, 2009·Journal of Clinical Pathology·C Miralles-GuriS de Sanjosé
Dec 7, 2018·Journal of the American Academy of Dermatology·Christopher T HaleyStephen K Tyring
Jun 9, 2010·Archives of Pathology & Laboratory Medicine·Elsa F VelazquezUNKNOWN Members of the Cancer Committee, College of American Pathologists
Mar 1, 2009·Surgical Pathology Clinics·Matthew J Wasco, Rajal B Shah
Aug 3, 2010·The Urologic Clinics of North America·Paul L Crispen, Jack H Mydlo
Aug 19, 2010·Urology·Alcides ChauxAntonio L Cubilla

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