Pseudomembraneous clostridium after autologous bone marrow transplantation

Bone Marrow Transplantation
P KavanL K McClain

Abstract

Clostridium difficile (C. difficile) pseudomembraneous colitis was diagnosed in a 13-year-old boy with Hodgkin's disease 3 months after autologous bone marrow transplantation. Hematopoiesis was fully reconstituted at the time. C. difficile infection occurred after gall bladder empyema had been treated conservatively with i.v. antibiotics and prophylactic 4-week administration of oral amoxicillin. C. difficile colitis was diagnosed early and intensive supportive therapy combined with administration of i.v. and subsequently oral vancomycin therapy failed. It is a phenomenon rarely seen and successful eradication of the clostridium infection was only achieved by a combination of higher dose vancomycin with metronidazole. During the post-colitis recovery the patient experienced a relapse of Hodgkin's disease and died following further surgical intervention 137 days post-transplantation.

Citations

May 24, 2005·Bone Marrow Transplantation·C C BarkerJ D Butzner
Sep 21, 2000·Journal of Pediatric Gastroenterology and Nutrition·L V McFarlandS Guandalini
Oct 27, 2010·Clinical Transplantation·Teena ChopraGeorge J Alangaden
Feb 1, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Erik R DubberkeVictoria J Fraser
Mar 3, 2019·Scandinavian Journal of Medicine & Science in Sports·Timo JaakkolaDavid F Stodden

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