Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis.

Nature Reviews. Microbiology
Elio RossiH K Johansen

Abstract

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF) airways has shown inefficient eradication of the infecting bacteria, as well as previously undocumented patient-to-patient transmission of adapted clones. However, genome sequencing has limited potential as a predictor of chronic infection and of the adaptive state during infection, and thus there is increasing interest in linking phenotypic traits to the genome sequences. Phenotypic information ranges from genome-wide transcriptomic analysis of patient samples to determination of more specific traits associated with metabolic changes, stress responses, antibiotic resistance and tolerance, biofilm formation and slow growth. Environmental conditions in the CF lung shape both genetic and phenotypic changes of P. aeruginosa during infection. In this Review, we discuss the adaptive and evolutionary trajectories that lead to early diversification and late convergence, which enable P. aeruginosa to succeed in this niche, and we point out how knowledge of these biological features may be used to guide diagnosis and therapy.

References

Jun 3, 1988·Science·J A Imlay, S Linn
Jan 1, 1987·Annual Review of Microbiology·J W CostertonT J Marrie
May 1, 1994·Trends in Microbiology·T B May, A M Chakrabarty
Feb 28, 2003·Lancet·Felix Ratjen, Gerd Döring
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeff G LeidAlyssa K Jeffers
Jan 25, 2006·Molecular Microbiology·James A Imlay
Sep 13, 2006·Infection and Immunity·Jinghua JiaShouguang Jin
Dec 19, 2006·Journal of Medical Microbiology·Spyros PournarasAthanassios Tsakris
Sep 1, 2007·The Journal of Infectious Diseases·Robert K ErnstSamuel I Miller
Sep 18, 2007·Journal of Bacteriology·Kelli L PalmerMarvin Whiteley
Aug 25, 2009·The Journal of Hospital Infection·K G Kerr, A M Snelling
Jun 18, 2010·Environmental Microbiology·Eliane FrimmersdorfDietmar Schomburg
Feb 8, 2011·American Journal of Respiratory and Critical Care Medicine·Eilidh MowatCraig Winstanley
Mar 3, 2011·FEMS Microbiology Reviews·Mark W SilbyRobert W Jackson
Apr 16, 2011·Environmental Microbiology·Nina CramerBurkhard Tümmler
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lei YangSøren Molin
Aug 3, 2011·Frontiers in Microbiology·Jens KlockgetherBurkhard Tümmler
Jun 22, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·T W V DanielsM P Carroll
Nov 14, 2012·Nature Reviews. Microbiology·Anders FolkessonSøren Molin
Mar 6, 2013·Expert Review of Anti-infective Therapy·Jack N PendletonBrendan F Gilmore
Mar 26, 2013·Current Opinion in Pulmonary Medicine·François BarbierLila Bouadma
Jul 6, 2013·Trends in Microbiology·Thomas BjarnsholtNiels Høiby
Mar 25, 2014·Nature Reviews. Microbiology·Victor ChubukovUwe Sauer
Apr 17, 2014·Nature Reviews. Microbiology·Pablo I NikelVíctor de Lorenzo

❮ Previous
Next ❯

Citations

Apr 4, 2021·International Journal of Molecular Sciences·Irene Jurado-MartínSiobhán McClean
Apr 6, 2021·Frontiers in Microbiology·Fernando BaqueroJose L Martinez
Apr 21, 2021·Antimicrobial Agents and Chemotherapy·John K CraneMark D Sutton
Aug 3, 2021·Journal of Bacteriology·Courtney E Price, George A O'Toole
Oct 11, 2021·The ISME Journal·Michael J BotteryVille-Petri Friman
Nov 16, 2021·Frontiers in Microbiology·Juan M BelardinelliMary Jackson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.