Pseudomonas aeruginosa Biofilm, a Programmed Bacterial Life for Fitness

Journal of Microbiology and Biotechnology
Keehoon Lee, Sang Sun Yoon


A biofilm is a community of microbes that typically inhabit on surfaces and are encased in an extracellular matrix. Biofilms display very dissimilar characteristics to their planktonic counterparts. Biofilms are ubiquitous in the environment and influence our lives tremendously in both positive and negative ways. Pseudomonas aeruginosa is a bacterium known to produce robust biofilms. P. aeruginosa biofilms cause severe problems in immunocompromised patients, including those with cystic fibrosis or wound infection. Moreover, the unique biofilm properties further complicate the eradication of the biofilm infection, leading to the development of chronic infections. In this review, we discuss the history of biofilm research and general characteristics of bacterial biofilms. Then, distinct features pertaining to each stage of P. aeruginosa biofilm development are highlighted. Furthermore, infections caused by biofilms on their own or in association with other bacterial species (i.e., multispecies biofilms) are discussed in detail.


Dec 12, 2018·Journal of Bacteriology·Courtney E ChandlerRobert K Ernst
Sep 13, 2018·Current Medicinal Chemistry·Grzegorz GułaZuzanna Drulis-Kawa
Apr 24, 2018·Pathogens and Disease·Dusan MilivojevicJasmina Nikodinovic-Runic
Dec 14, 2019·Applied Microbiology and Biotechnology·Xiao JiaYi Xiao
Aug 5, 2020·Expert Review of Anti-infective Therapy·Rakesh Sikdar, Mikael Elias
May 31, 2020·The European Respiratory Journal·Benedicte De MuynckLeuven Lung Transplant Group
May 22, 2020·European Journal of Medical Research·Mina Pourmbarak Mahnaie, Hassan Mahmoudi
Jun 9, 2020·Frontiers in Microbiology·Musa Hassan MuhammadTianpei Huang
Nov 5, 2020·PloS One·Luna GirolaminiSandra Cristino

Related Concepts

Pseudomonas Infections
Stokesia (plankton genus)
Pseudomonas aeruginosa (antigen)
Extracellular Matrix
Secondary Infections
Disease Eradication
Cystic Fibrosis

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