Pseudomonas aeruginosa Biofilms.

International Journal of Molecular Sciences
Minh Tam Tran ThiBernd H A Rehm

Abstract

Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Its highly notorious persistence in clinical settings is attributed to its ability to form antibiotic-resistant biofilms. Biofilm is an architecture built mostly by autogenic extracellular polymeric substances which function as a scaffold to encase the bacteria together on surfaces, and to protect them from environmental stresses, impedes phagocytosis and thereby conferring the capacity for colonization and long-term persistence. Here we review the current knowledge on P. aeruginosa biofilms, its development stages, and molecular mechanisms of invasion and persistence conferred by biofilms. Explosive cell lysis within bacterial biofilm to produce essential communal materials, and interspecies biofilms of P. aeruginosa and commensal Streptococcus which impedes P. aeruginosa virulence and possibly improves disease conditions will also be discussed. Recent research on diagnostics of P. aeruginosa infections will be investigated. Finally, therapeutic strategies for the treatment of P. aeruginosa biofilms along with their advantages and limitations will be compiled.

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Citations

Jan 26, 2021·Current Opinion in Infectious Diseases·Nikolaos SpernovasilisGaryfallia Poulakou
Mar 7, 2021·International Journal of Molecular Sciences·Lukas HofmannSharon Ruthstein
Jul 3, 2021·International Journal of Molecular Sciences·Natalia CzaplickaDonata Konopacka-Łyskawa
Jul 3, 2021·International Journal of Molecular Sciences·Nikita SuvorovMikhail Grin
Jul 27, 2021·Frontiers in Microbiology·Zhaowei JiangJing Yan
Oct 31, 2021·Applied Microbiology and Biotechnology·Rachith KalgudiTajalli Keshavarz

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Methods Mentioned

BETA
environmental stress
PCR
Biosensor
biosensors

Software Mentioned

MicroScan WalkAway

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