PMID: 9632568Jun 25, 1998Paper

Pseudomonas aeruginosa exoenzyme S is a mitogen but not a superantigen for human T lymphocytes

Infection and Immunity
T F BrunoC H Mody

Abstract

Virtually all cystic fibrosis (CF) patients become infected with Pseudomonas aeruginosa, and once the infection is established, the organism is rarely cleared. One of the P. aeruginosa virulence factors, exoenzyme S, has been shown to correlate with increased morbidity and mortality both in rat models of chronic pulmonary inflammation and in human CF patients. It has previously been shown that exoenzyme S is a potent stimulus for the proliferation of T cells in greater than 95% of adults, which could contribute to the pathogenesis of CF. The goal of this study was to determine the mechanism of T-cell stimulation by exoenzyme S in an effort to shed light on the immune response and contribute to understanding its role in P. aeruginosa pathogenesis. The current studies demonstrate that exoenzyme S stimulates naive T cells, since fetal blood lymphocytes proliferated and adult lymphocytes that expressed CD45RA proliferated. The percentage of T cells activated by exoenzyme S after a 4-h culture (as measured by CD69 surface expression) was intermediate in magnitude compared to levels induced by a panel of superantigens and mitogens. To determine the mechanism of activation, the requirement for accessory cells was investigated. The pro...Continue Reading

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Citations

Jan 1, 2017·Journal of the Chinese Medical Association : JCMA·Waheed UllahNoor Muhammad
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Slava EpelmanChristopher H Mody
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans X HoyerRudolf M Huber
Feb 7, 2002·Biochemical and Biophysical Research Communications·Jennifer E FraylickJoan C Olson

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