PMID: 9174204Jun 1, 1997Paper

Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region

Antimicrobial Agents and Chemotherapy
J I CampbellN Høiby

Abstract

Pseudomonas aeruginosa isolates from 1 of 17 cystic fibrosis patients produced secondary beta-lactamase in addition to the ampC beta-lactamase. Isolates were grouped into three beta-lactamase expression phenotypes: (i) beta-lactam sensitive, low basal levels and inducible beta-lactamase production; (ii) beta-lactam resistant, moderate basal levels and hyperinducible beta-lactamase production; (iii) beta-lactam resistant, high basal levels and constitutive beta-lactamase production. Apart from a base substitution in the ampR-ampC intergenic region of an isolate with moderate-basal-level and hyperinducible beta-lactamase production, sensitive and resistant strains were identical in their ampC-ampR genetic regions. Thus, enhanced beta-lactamase expression is due to mutations in regulatory proteins other than AmpR.

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Citations

Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Shu-Fen WengYi-Hsiung Tseng
Jan 1, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Kok-Fai KongKalai Mathee
May 1, 2013·The Journal of Antimicrobial Chemotherapy·Catherine LlanesUNKNOWN GERPA Study Group
Jul 17, 1999·European Journal of Biochemistry·J Walther-RasmussenN Høiby
Jun 7, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ming NiJunying Qi
Sep 10, 2008·Antimicrobial Agents and Chemotherapy·Amber J Schmidtke, Nancy D Hanson
Apr 25, 2018·Nature Ecology & Evolution·Danna R GiffordR Craig MacLean
May 23, 2007·Antimicrobial Agents and Chemotherapy·Daniel J WolterPhilip D Lister
May 26, 2006·Antimicrobial Agents and Chemotherapy·Amber J Schmidtke, Nancy D Hanson
May 1, 1999·Antimicrobial Agents and Chemotherapy·T NaasP Nordmann
Dec 3, 1998·Antimicrobial Agents and Chemotherapy·T Y LangaeeA Huletsky
Jun 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G M Rossolini, E Mantengoli

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