Pseudomyogenic hemangioendothelioma of skin, bone and soft tissue-a clinicopathological, immunohistochemical, and fluorescence in situ hybridization study

Human Pathology
Dinesh PradhanUma N M Rao

Abstract

Pseudomyogenic hemangioendothelioma (PHE) is an uncommon neoplasm with propensity for local recurrence. The tumor mimics epithelioid hemangioendothelioma and epithelioid sarcoma, representing a possible diagnostic pitfall. We investigated the clinicopathological, immunohistochemical, and fluorescence in situ hybridization features of PHEs. Eight cases of PHE were retrieved from our pathology archives. The clinical and outcome information was available in 6 patients. In 6 cases, the tumors were located in the lower limb, whereas the upper limb was involved in 2 cases. Three patients had exclusively bone involvement, and 2 patients had cutaneous tumor only. The tumor was multifocal in 5 cases, of which 2 patients had simultaneous bone and soft tissue involvement. Immunohistochemical stains revealed all tumors to be positive for AE1/AE3 (8/8), ERG (7/7), and FLI-1 (7/7) with preserved INI1 (7/7) expression. Most of the tumors were variably positive for CD31 (7/8), CAM5.2 (2/3), and SMA (4/6). t(7;19)(q22;q13) fusion pattern was detected in 3 cases (5 tumors) with cutaneous and multifocal PHE. In 3 cases, a translocation pattern was detected in a few nuclei but did not meet our laboratory cutoff value. MYC amplification was not det...Continue Reading

Citations

Sep 27, 2018·The American Journal of Surgical Pathology·Narasimhan P AgaramCristina R Antonescu
Jan 26, 2020·Virchows Archiv : an International Journal of Pathology·Yuefang SunJian Wang
May 28, 2019·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Shin-Ichi AnsaiSatoshi Akaishi
Feb 10, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Rong-Hui XiaJiang Li
Oct 13, 2021·Diagnostic Cytopathology·Bryce S HatfieldSadia Sayeed

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