PMID: 8599441Jun 1, 1995Paper

"Pseudoneoplastic" leprosy. Leprosy revisited

The American Journal of Dermatopathology
J A TriscottM R Wick

Abstract

A 70-year-old Italian man with a history of squamous cell carcinoma of the lung presented with a nodular skin eruption. He had traveled extensively in India and Sri Lanka. The nodules were well demarcated and measured up to 3.5 cm in diameter. Histologically, there was a proliferation of spindled and polygonal cells with focal and relatively inconspicuous cytoplasmic vacuolation. A macrophage-monocyte lineage for the cells was confirmed by paraffin section immunohistochemistry, using the monoclonal antibodies anti-CD45, MAC-387, KP-1, UCHL-1, MT-1, L26, and MB2. Infiltrating borders, extension of the lesion into the subcutis, and involvement of small dermal nerves and eccrine glands initially suggested the possibility of a "histiocytic" neoplasm of indeterminate biological potential. However, air-dried and Giemsa-stained material from a fine-needle aspirate of one cutaneous nodule showed needle-shaped intracellular "negative images," and acid-fast stains revealed a large number of intracytoplasmic bacilli in virtually all of the vacuolated lesional cells. Furthermore, a second skin nodule that was excised 3 weeks after initial presentation showed the typical morphology of lepromatous leprosy. The clinicopathologic features of t...Continue Reading

Citations

Nov 23, 2007·The American Journal of Dermatopathology·Ryan S JawitzMichael B Morgan
Jun 17, 2010·Indian Journal of Pathology & Microbiology·S Jahnavi, S M Nyasavajjala
Jul 4, 2019·The American Journal of Dermatopathology·Egon L Rodrigues DaxbacherThiago Jeunon

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