Pseudoprogression: an indicator for cure in combined immunotherapy?

Immunotherapy
Lingdi ZhaoQuanli Gao

Abstract

Pseudoprogression is a unique, uncommon phenomenon that often hints at good prognosis. To date, there has been no report of complete remission after pseudoprogression. Here, we report successful treatment of metastatic renal clear cell cancer, using anti-PD-1 antibodies combined with autologous RetroNectin-activated cytokine-induced killer cells, in two patients who were failed to multitargeted kinase inhibitors. After early pseudoprogression, complete remission was achieved. At present, one patient has stopped therapy for about 1.5 years and is still disease free.

References

Mar 9, 2012·The New England Journal of Medicine·Michael A PostowJedd D Wolchok
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Nov 30, 2012·Clinical & Developmental Immunology·Clara E JäkelIngo G H Schmidt-Wolf
Mar 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne L TopalianF Stephen Hodi
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David F McDermottMichael B Atkins
Aug 12, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Victoria L Chiou, Mauricio Burotto
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Apr 8, 2016·Expert Opinion on Therapeutic Patents·Matthieu Collin
May 4, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rita NandaLaurence Buisseret
Jul 20, 2016·Journal of Immunology Research·Lu HanQuan-Li Gao
Apr 12, 2017·Nature·Alexander C HuangE John Wherry
Jun 27, 2017·The Journal of Clinical Investigation·Mark AyersTerrill K McClanahan
Mar 6, 2018·The Journal of Clinical Investigation·Dmitriy ZamarinJedd D Wolchok
Mar 22, 2018·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 214 Investigators

❮ Previous
Next ❯

Citations

Jul 21, 2020·Future Oncology·Roberto Ferrara, Ignacio Matos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Liang LiuXiubao Ren
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Karen L Reckamp
© 2021 Meta ULC. All rights reserved