Pseudoprogression as an adverse event of glioblastoma therapy

Cancer Medicine
Carmen BalañaGLIOCAT Group

Abstract

We explored predictive factors of pseudoprogression (PsP) and its impact on prognosis in a retrospective series of uniformly treated glioblastoma patients. Patients were classified as having PsP, early progression (eP) or neither (nP). We examined potential associations with clinical, molecular, and basal imaging characteristics and compared overall survival (OS), progression-free survival (PFS), post-progression survival (PPS) as well as the relationship between PFS and PPS in the three groups. Of the 256 patients studied, 56 (21.9%) were classified as PsP, 70 (27.3%) as eP, and 130 (50.8%) as nP. Only MGMT methylation status was associated to PsP. MGMT methylated patients had a 3.5-fold greater possibility of having PsP than eP (OR: 3.48; 95% CI: 1.606-7.564; P = 0.002). OS was longer for PsP than eP patients (18.9 vs. 12.3 months; P = 0.0001) but was similar for PsP and nP patients (P = 0.91). OS was shorter-though not significantly so-for PsP than nP patients (OS: 19.5 vs. 27.9 months; P = 0.63) in methylated patients. PPS was similar for patients having PsP, eP or nP (PPS: 7.2 vs. 5.4 vs. 6.7; P = 0.43). Neurological deterioration occurred in 64.3% of cases at the time they were classified as PsP and in 72.8% of cases of e...Continue Reading

References

Jan 1, 1997·Anti-cancer Drugs·S R WedgeE S Newlands
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Jeremy D RubenPasqual Fedele
Sep 1, 2006·Journal of Neuro-oncology·Marc C ChamberlainAndrew E Sloan
May 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
May 3, 2008·The Lancet Oncology·Dieta BrandsmaMartin J van den Bent
Sep 29, 2009·International Journal of Radiation Oncology, Biology, Physics·Brian J BlonigenJohn C Breneman
Oct 17, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gloria B RoldánJacob C Easaw
Feb 23, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Paul SangheraMay N Tsao
Mar 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Yaacov Richard LawrenceAdam P Dicker
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Apr 7, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina TsienBrian D Ross
Jul 16, 2010·Clinical Neurology and Neurosurgery·Emel YamanRamazan Yildiz
Aug 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Kyle E RusthovenChanghu Chen
Nov 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christina I TsienTheodore Lawrence
Apr 3, 2013·Expert Review of Neurotherapeutics·Tim J KruserH Ian Robins
May 18, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E Van MieghemP M Clement
Jul 6, 2014·International Journal of Molecular Sciences·Kashif ParvezGelareh Zadeh
Jul 20, 2014·Neuro-oncology·Alexander RadbruchMartin Bendszus
Nov 21, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Norbert GalldiksKarl-Josef Langen
Apr 22, 2015·Journal of Neuro-oncology·Isaac Melguizo-GavilanesVinay K Puduvalli
Nov 27, 2015·Journal of Neuro-oncology·Hun Ho ParkJong Hee Chang
Jan 7, 2017·Journal of Korean Neurosurgical Society·Brian SnellingRonald Benveniste
Jun 13, 2017·International Journal of Radiation Oncology, Biology, Physics·Douglas Guedes de CastroElena Fidarova

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Citations

May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Stefanie C ThustMarion Smits
May 9, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C BalañaS Villà
Nov 22, 2019·The Oncologist·Jacob J AdashekRazelle Kurzrock
Jul 9, 2020·International Journal of Molecular Sciences·Susannah HallalKimberley Louise Alexander-Kaufman
Nov 10, 2018·Insights Into Imaging·Alexander T Kessler, Alok A Bhatt
Jan 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel Rodriguez GutierrezTim Jaspan
Dec 31, 2020·Cancers·Cristina BirzuGiuseppe Lombardi
Feb 12, 2020·The Oncologist·Jacob J AdashekRazelle Kurzrock
Dec 15, 2020·Seminars in Ultrasound, CT, and MR·Benjamin R GrayNicholas A Koontz
May 6, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jan-Michael WernerNorbert Galldiks

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Methods Mentioned

BETA
PCR
total resection

Software Mentioned

GLIOCAT

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