PMID: 11900841Mar 20, 2002Paper

Pseudorabies virus (PRV) is protected from complement attack by cellular factors and glycoprotein C (gC)

Virus Research
Kohshi MaedaHaruki Otsuka

Abstract

Swine kidney derived CPK cells were resistant to swine complement attack in vitro while rabbit kidney derived RK13 cells were destroyed by swine complement. To rabbit complement, RK13 cells were resistant but CPK cells were sensitive. This phenomenon was known as homologous restriction (Proc. Natl. Acad. Sci. USA 78 (1981) 5118). The gC deletion mutant of pseudorabies virus (PRVdlgC) grown in CPK cells was resistant to swine complement while the same virus grown in RK13 cells was neutralized by swine complement. PRVdlgC grown in RK13 cells was more resistant to rabbit complement than the virus grown in CPK cells. Hence, the sensitivity of PRVdlgC to swine or rabbit complement was similar to that of the cells in which the virus was grown. It would appear that cell derived factors were present on the virion and they were protective against homologous complement but not against heterologous complement. The expression of gC rendered PRV more resistant to swine or rabbit complement, but the protective effect of gC was much less than that of cell derived factors. The best protection against complement was obtained when gC and cell derived factors were coexistent on the virion.

References

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Citations

Feb 8, 2006·The Journal of Veterinary Medical Science·Tatiana A BatanovaYasuhiro Takashima
Jan 21, 2003·The Journal of General Virology·Herman W FavoreelMaurice B Pensaert
Dec 21, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mingming ZhouYijun Du

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