Pseudotumour cerebri, CSF rhinorrhoea and the role of venous sinus stenting in treatment

British Journal of Neurosurgery
Brian K OwlerMichael Besser

Abstract

We present a case of pseudotumour cerebri (PTC), which is important as it illustrates the effects of chronically raised CSF pressure, the relationship between PTC and venous sinus obstruction and the successful treatment of PTC using a venous sinus stent. A 38-year-old woman, previously diagnosed with PTC and unsuccessfully treated 10 years previously re-presented with spontaneous CSF rhinorrhoea. Imaging revealed dramatic changes of chronically raised CSF pressure and a defect in the anterior cranial fossa. The CSF leak was corrected surgically and a lumbo-peritoneal shunt inserted to correct a large postoperative subgaleal CSF collection. Direct retrograde cerebral venography (DRCV) demonstrated venous sinus obstruction due to a filling defect. This was associated with a pressure gradient and a high superior sagittal sinus pressure. The venous sinus obstruction was successfully treated with a venous sinus stent and the lumbo-peritoneal shunt was removed. Chronically raised CSF pressure in untreated cases of PTC may cause widespread changes in the skull, which in this case, culminated in a spontaneous CSF leak despite relatively mild headache and visual symptoms. Furthermore, cases of PTC secondary to venous sinus obstruction ...Continue Reading

References

Jun 1, 1975·Neurology·K M Foley, J B Posner
Aug 1, 1975·Journal of Neurosurgery·L A WeisbergD P Saur
Dec 1, 1992·Developmental Medicine and Child Neurology·M B ConnollyO Flodmark
Jan 1, 1991·British Journal of Neurosurgery·M S Eljamel, P M Foy
Jan 1, 1989·Radiology·R SilbergleitM K Hatfield
Mar 1, 1970·Archives of Neurology·R BrismanL A Mount
Jan 1, 1970·Brain : a Journal of Neurology·H DavsonM B Segal
Aug 1, 1995·Neuroradiology·L ManfréA E Cardinale
Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·D ClarkJ Firth
Nov 1, 1996·Neuroradiology·A GassD H Miller
Jan 27, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·L R CamrasC A Abood
Oct 1, 1998·Ophthalmology·M C Brodsky, M Vaphiades
Jan 29, 2002·Lancet·J Nicholas P HigginsJohn D Pickard

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Citations

Mar 3, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Brian K Owler, Michael Besser
Feb 27, 2004·Current Neurology and Neuroscience Reports·Paul W Brazis
May 18, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Eldar RosenfeldAnat Kesler
Dec 3, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Paul W Brazis
Nov 29, 2008·Cephalalgia : an International Journal of Headache·P W Brazis
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J N P HigginsJ D Pickard
Jan 1, 2009·Journal of Ophthalmology·Simon R BababeygyPrem S Subramanian
Sep 4, 2004·Neurosurgical Focus·Sanjay N Misra, Ashish K Misra
May 5, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gary HunterMichele Rajput
Aug 9, 2011·Otolaryngologic Clinics of North America·Eric W WangRodney J Schlosser
Jul 2, 2016·Asian Journal of Neurosurgery·Yad Ram YadavHemant Namdev
Dec 10, 2014·The Neuroradiology Journal·Yosra Abdelzaher IbrahimJeevak Almast
Nov 3, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Theodore A Schuman, Brent A Senior
Oct 13, 2005·Acta Neurologica Scandinavica·M Mezaal, M Saadah
Sep 18, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Mario A PérezValérie Biousse
Feb 13, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Samuel BidotValérie Biousse
Aug 26, 2011·Neurosurgery·Shervin R DashtiDavid Fiorella
Jun 1, 2007·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·R CrosaP Lasjaunias
Mar 19, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Bryce BuchowiczUNKNOWN CSF-Leak Study Group

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