PMID: 15232310Jul 3, 2004Paper

Pseudouveitis: a clue to the diagnosis of primary central nervous system lymphoma in immunocompetent patients

Medicine
Sophie ParkPhilippe Blanche

Abstract

Primary oculocerebral non-Hodgkin lymphoma (NHL) of the immunocompetent patient is associated with significant morbidity and mortality, but early diagnosis and follow-up may improve prognosis. The eye, anatomically and embryologically part of the central nervous system (CNS), can be the primary site of the lymphomatous process. In patients with symptoms of atypical uveitis, vitrectomy can be of great help for early diagnosis of primary central nervous system lymphoma. We retrospectively reviewed the diagnostic features, treatment, and evolution of 10 patients with primary central nervous system lymphoma who presented with symptoms of pseudouveitis. The patients complained of chronic vitreal opacities, increasing with time. These symptoms contrasted with the absence of the usual signs of inflammation of the anterior segment or of the retina, which characterize true uveitis. Vitrectomy was proposed after lumbar puncture and cerebral magnetic resonance imaging. Six vitrectomies were carried out, 3 patients had a stereotaxic biopsy, and 1 patient had a cardiac biopsy. A pathologic diagnosis of large B-cell lymphoma was made on vitrectomy specimens in 100% of the patients who had this procedure. The mean time from onset of ocular sy...Continue Reading

References

Aug 15, 1990·American Journal of Ophthalmology·M D de SmetR B Nussenblatt
May 15, 1989·Cancer·J A StrauchenA H Friedman
Dec 1, 1988·The British Journal of Ophthalmology·D H CharT R Miller
Jun 1, 1988·Journal of Neurosurgery·F H Hochberg, D C Miller
Oct 1, 1987·The British Journal of Ophthalmology·M H KirmaniR P Laborde
Nov 1, 1995·American Journal of Ophthalmology·C C ChanR B Nussenblatt
Sep 1, 1993·Ophthalmology·S M WhitcupR B Nussenblatt
May 1, 1993·Ophthalmology·D F MartinR B Nussenblatt
Sep 23, 1997·Archives of Ophthalmology·B C FishburneE A Neuwelt
Jul 25, 1998·Klinische Monatsblätter für Augenheilkunde·J J TrittenC P Herbort
Aug 6, 1999·The British Journal of Ophthalmology·M D de SmetC C Chan
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C SoussainV Leblond
Aug 8, 2002·Journal of Neuro-oncology·Raja B KhanLauren E Abrey
Jan 7, 2003·Clinical Oncology : a Journal of the Royal College of Radiologists·P N PlowmanC Pavesio
Feb 18, 2003·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H HelbigM D de Smet

❮ Previous
Next ❯

Citations

Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alain P AlgaziJames L Rubenstein
Jan 1, 2014·Ocular Immunology and Inflammation·Monica DalalH Nida Sen
Feb 15, 2020·Survey of Ophthalmology·Alexandra L Farrall, Justine R Smith
Jan 28, 2009·Survey of Ophthalmology·Nathan M Radcliffe, Paul T Finger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Manuel CappellariMaria Donata Benedetti
Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
A B FierzA M Thoelen
© 2022 Meta ULC. All rights reserved