[PSMA-Radioguided Surgery for Salvage Lymphadenectomy in Recurrent Prostate Cancer].

Aktuelle Urologie
Isabel RauscherTobias Maurer

Abstract

Recently, the use of 111In-labeled PSMA-I&T-based radioguided surgery (111In-PSMA-RGS) for salvage surgery using intraoperative ex-vivo γ-probe measurements has been described by our group as a promising new and individual treatment concept in patients with localised recurrent prostate cancer (PC). 111In-PSMA-RGS allowed for the intraoperative identification of metastatic lesions with a sensitivity, specificity and accuracy of 92.3, 93.5 and 93.1%, respectively, compared to histopathology. 111In-PSMA-RGS was able to detect 5 additional lymph node metastases in 3 out of 31 patients compared to 68Ga-HBED-CC-PSMA PET. A PSA decline >50 and >90% was observed in 24/31 patients and 17/31 patients, respectively. In 19/31 patients even a complete biochemical response was observed. 10/31 patients received further PC-specific treatment after a median of 125 days following 111In-PSMA-RGS. Surgery-related complications were observed in 10 patients (Clavien-Dindo classification: grade 1 n=6, grade 3b n=4). 111In-PSMA-RGS seems to be highly valuable for the intraoperative detection of small metastatic lesions in PC patients scheduled for salvage lymphadenectomy. It allows for an exact localisation and resection of metastatic tissue during 11...Continue Reading

Citations

Mar 21, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ingrid L BakkerSimone U Dalm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.