PSMA5 promotes the tumorigenic process of prostate cancer and is related to bortezomib resistance

Anti-cancer Drugs
Zhenrui FuBaomin Qiao

Abstract

Proteasome α5 subunit (PSMA5) is related to poor prognosis in various cancers. The first therapeutic proteasome inhibitor, bortezomib, induces apoptosis, suppressing cell growth in many tumor types. However, the effects of PSMA5 and bortezomib in prostate cancer (PCa) are still unknown. In this study, we investigated whether PSMA5 is associated with the tumorigenic progression and the interaction of PSMA5 with bortezomib in PCa. We knocked down PSMA5 with siRNA and studied the changes in cell viability and motility with Cell Counting Kit-8, quantitative PCR, fluorescence-activated cell sorting, scratch, and invasion assays. We also investigated the effect of PSMA5 in PCa cells treated with bortezomib and in those that are resistant to bortezomib. We found that silencing PSMA5 inhibited cell proliferation, induced apoptosis, restricted cell migration and invasion, and demonstrated a coordinated effect with bortezomib. Cells resistant to bortezomib gained sensitivity to bortezomib after PSMA5 was knocked down. Our results show, for the first time, that PSMA5 promotes the tumorigenic process of PCa and is linked to bortezomib resistance.

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·A Ciechanover, A L Schwartz
Mar 28, 2002·Physiological Reviews·Michael H Glickman, Aaron Ciechanover
Jun 29, 2010·Urologic Oncology·Ioannis A Voutsadakis, Christos N Papandreou
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 6, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Azmi YerlikayaEngin Ulukaya
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 24, 2014·Nature Reviews. Molecular Cell Biology·Sucharita BhattacharyyaAndreas Matouschek
May 20, 2017·Cell·Galen Andrew Collins, Alfred L Goldberg
Sep 28, 2017·Oncotarget·Alessandra LaroccaMario Boccadoro

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