PMID: 9544188Apr 17, 1998Paper

Psoralen photochemotherapy, clinical efficacy, and photomutagenicity: the role of molecular epidemiology in minimizing risks

Environmental and Molecular Mutagenesis
F P GasparroJ M McNiff

Abstract

Photochemotherapy employing 8-methoxypsoralen and ultraviolet radiation (PUVA) is widely used in the treatment of psoriasis. The photoactivation of psoralens in skin cells leads to DNA photoadduct formation which may be responsible for the efficacy of PUVA. Subsequent mutations may lead to the increased incidence of squamous cell carcinoma (SCC). Mutations in the p53 tumor suppressor gene have been detected in many human cancers. In this review, p53 mutation spectra in murine and human SCC are compared to those obtained from murine cells and skin treated with PUVA as well as to the p53 mutation spectrum in human solar SCC. While the expected psoralen-type mutations at alternating AT sites were detected in the treated cells and murine SCC (average frequency > 40%), such mutations were not commonly detected in the human SCC (< 10%). Other common mutations in the human SCC included: CG-->TA transitions (18%) and CG-->AT and TA-->GC transversions (17 and 25%, respectively). In addition, the frequency of UVB-type mutations at dipyrimidine sites (CC-->TT) in the SCC PUVA-treated psoriasis patients was comparable to that in patients with SCC from only solar exposure. A review of therapeutic history of these patients showed that many h...Continue Reading

Citations

Dec 10, 2002·Experimental Gerontology·Wenjian MaKarin Scharffetter-Kochanek
Mar 31, 1999·Journal of Dermatological Science·D BetheaF P Gasparro
Apr 25, 2008·Journal of the American Academy of Dermatology·Laurent Marrot, Jean-Roch Meunier
Apr 11, 2008·Phytochemical Analysis : PCA·Laura BissonnetteMyron L Smith
Oct 27, 1999·Journal of the American Academy of Dermatology·F P Gasparro

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