Psoriasis: A possible reservoir for human papillomavirus type 5, the virus associated with skin carcinomas of epidermodysplasia verruciformis

The Journal of Investigative Dermatology
M FavreStefania Jablonska

Abstract

Recent polymerase chain reaction data have shown that most human papillomavirus (HPV) genotypes associated with epidermodysplasia verruciformis (EV) are widespread; however, HPV5 associated with EV skin carcinomas has only rarely been detected in non-EV patients. To identify the reservoir of this virus, we examined 335 sera from different groups of patients for the presence of HPV5 antibodies by an enzyme-linked immunosorbent assay test based on HPV5 virus-like particles. The prevalence of antibodies reacting with HPV5 virus-like particles was found to be significantly higher in psoriatic patients (24.5%) than in other groups (2-5%), including patients with atopic dermatitis and renal transplant recipients. Analysis of scrapings of lesional and uninvolved skin by a nested polymerase chain reaction method, using degenerate EV HPV primers, disclosed HPV DNA in 91.7% of 48 psoriatic skin samples and 35.5% of 31 atopic dermatitis specimens. Eleven EV HPV genotypes, most frequently HPV5 and HPV36, and a putative novel genotype (PsoX1) were identified in psoriasis. Five EV HPV genotypes and two putative novel genotypes (ADX1 and ADX2) were detected in atopic dermatitis patients. HPV5 was not found in atopic dermatitis patients. Using...Continue Reading

Citations

Sep 1, 1999·The British Journal of Dermatology·I L BoxmanJ Ter Schegget
Sep 5, 2002·International Journal of Dermatology·Virendra N SehgalPromila Bajaj
Sep 8, 2011·Human Molecular Genetics·Dan ChenPaul Brennan
Nov 8, 2005·Journal of Clinical Microbiology·Antoinette A T P BrinkPeter J F Snijders
Jun 3, 2009·Microbiology and Molecular Biology Reviews : MMBR·Maciej LazarczykMichel Favre
Jun 21, 2008·PLoS Pathogens·Kristina M MichaelMichael Pawlita
Nov 12, 2003·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Marina Jovanović, Dordije Karadaglić
Mar 11, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ingo NindlEggert Stockfleth
Apr 20, 1999·International Journal of Dermatology·S Jablonska, S Majewski
Jul 5, 2005·Expert Opinion on Investigational Drugs·B J Nickoloff
Apr 2, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·A B JensonS Ghim
Apr 2, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·J N Bouwes BavinckJ ter Schegget
Nov 6, 1998·The Journal of Investigative Dermatology·E Mahe, V Descamps
Sep 18, 1998·The Journal of Investigative Dermatology·S MajewskiS Jablonska
Nov 20, 2009·The Journal of Investigative Dermatology·Kristina M MichaelMichael Pawlita
Feb 26, 2000·The Journal of Investigative Dermatology·M FavreS Jablonska
Jun 4, 2004·The Journal of Investigative Dermatology·Fabian TermorshuizenHenk van Loveren
Nov 17, 2001·The Journal of Investigative Dermatology·I L BoxmanUNKNOWN Collaborators of the Nambour Prevention Study
Oct 17, 2008·The Journal of Investigative Dermatology·Valentina Dell'OsteMarisa Gariglio
Nov 21, 2007·Clinics in Dermatology·Lionel Fry, Barbara S Baker
Jul 3, 2004·International Journal of Dermatology·Craig G Burkhart
Jul 21, 2005·The British Journal of Dermatology·J-P MolèsJ-J Guilhou
Oct 20, 2005·Experimental Dermatology·Paola SimeoneAldo Venuti
May 15, 2009·International Journal of Cancer. Journal International Du Cancer·Giuseppe BorzacchielloM Saveria Campo
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·S Jablonska, S Majewski
Apr 20, 2004·International Journal of Dermatology·Slawomir Majewski, Stefania Jablonska
Mar 15, 2006·International Journal of Dermatology·Slawomir Majewski, Stefania Jablonska
Apr 17, 2008·International Journal of Dermatology·Sandra Rodríguez-MartínezMario Eugenio Cancino-Diaz
Jul 27, 2006·The Australasian Journal of Dermatology·Michael R Lee, Alan J Cooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.