Psoriasis and multiple sclerosis: is there a link?

Journal of Cutaneous Medicine and Surgery
Tiffany KwokLyn Guenther

Abstract

psoriasis and multiple sclerosis (MS) are both autoimmune T cell-mediated diseases. Some case series have suggested an association. to investigate the potential relationship between psoriasis and MS based on a systematic review of the literature. medline, Cochrane Library, and EMBASE searches were performed. T-helper 17 cells are involved in the pathogenesis of both psoriasis and MS. Both conditions have been associated with interleukin-23 receptor (IL23R) polymorphisms. Studies have reported psoriasis in 0.41 to 7.7% of individuals with MS. A higher rate of psoriasis compared to controls was noted in a few small MS cohorts, but the number of cases was too small to draw any firm conclusions. In two studies, including a large Canadian study of 5,031 patients with MS, there was no increased prevalence of psoriasis in patients over the control population. Family members of individuals with MS do not appear to be at increased risk for psoriasis in these studies. Psoriasis has developed during treatment for MS, and MS has developed during treatment for psoriasis. although there are some common genetic linkages in psoriasis and MS, psoriasis does not appear to be more common in patients with MS or their relatives.

References

Feb 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S Warren, K G Warren
May 1, 1996·Acta Neurologica Scandinavica·R MidgardH Nyland
May 29, 2000·Brain : a Journal of Neurology·S A BroadleyD A Compston
Aug 16, 2000·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·R D HendersonM P Pender
Jul 14, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·C FerrándizA Smandía
Apr 16, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Robert S SternTara Rolstad
Dec 21, 2005·Archives of Dermatology·Joel M GelfandDavid J Margolis
Dec 31, 2005·Journal of the American Academy of Dermatology·Sean A SukalRichard D Granstein
Jun 15, 2007·Lancet Neurology·Sreeram Varadharajan RamagopalanUNKNOWN Canadian Collaborative Study Group
Oct 16, 2007·European Neurology·Maria Gomez-GallegoAndres Fernandez-Barreiro
Dec 18, 2007·Human Immunology·Ann B BegovichJorge R Oksenberg
Feb 15, 2008·The Journal of Dermatological Treatment·Alice B GottliebFrank Dann
Mar 28, 2008·Genes and Immunity·C NúñezA Martínez
Jul 11, 2008·Immunological Reviews·Laura A TesmerDavid A Fox
Feb 3, 2009·The British Journal of Dermatology·I López-LermaC Herrero

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Citations

Oct 26, 2012·Journal of Neurology·Jorge Millán-PascualSantiago Navarro-Muñoz
May 2, 2014·Clinical and Experimental Dermatology·C ZeccaC Gobbi
Mar 16, 2012·Multiple Sclerosis : Clinical and Laboratory Research·H RoshanisefatS Montgomery
Jul 2, 2011·Clinical and Experimental Dermatology·A C FoulkesR B Warren
Jun 14, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·G MironA Barzilai
Oct 27, 2018·American Journal of Clinical Dermatology·Chia-Yu LiuChing-Chi Chi
Sep 4, 2013·Case Reports in Neurological Medicine·Jasem Yousef Al-HashelWalaa Ahmed
Oct 24, 2017·The Journal of Dermatological Treatment·Mina AminJashin J Wu
Dec 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·U Gieler
Feb 17, 2021·Neurology. Neuroimmunology and Neuroinflammation·Regina BerkovichLawrence Steinman
Oct 17, 2018·Case Reports in Neurology·Sakis LambrianidesMarios Pantzaris
May 3, 2011·Current Opinion in Neurology

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