Psoriasis and risk of diabetes-associated microvascular and macrovascular complications

Journal of the American Academy of Dermatology
April W ArmstrongParvez Mulani

Abstract

Psoriasis's effect on diabetes onset is well documented, but its effect on course of diabetes is poorly understood. We sought to compare risks of developing microvascular and macrovascular complications between diabetic patients with and without psoriasis. Adults with 2 or more diabetes diagnoses selected from MarketScan databases (Truven Health Analytics Inc, Ann Arbor, MI) (2000-2006) were classified into 2 cohorts: 2 or more psoriasis diagnoses and without psoriasis diagnosis. Patients with psoriasis were matched using propensity score, and exactly matched using age, sex, and diabetes characteristics with patients without psoriasis. Outcomes were compared between cohorts using Cox regression models. In all, 6164 diabetic patients with psoriasis (27% moderate to severe) were matched to 6164 diabetic patients without psoriasis. Patients with psoriasis were significantly more likely to develop microvascular events than patients without psoriasis overall (hazard ratio [HR] 1.14, P < .001) and by psoriasis severity (mild: HR 1.13, P = .004; moderate to severe: HR 1.16, P = .038). Risk of macrovascular events was higher for patients without psoriasis overall (HR 1.13, P = .001) and those with mild psoriasis (HR 1.15, P = .003), bu...Continue Reading

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Citations

Mar 19, 2016·The British Journal of Dermatology·G ShalomA D Cohen
Feb 19, 2017·Journal of the American Academy of Dermatology·Junko TakeshitaJoel M Gelfand
Feb 19, 2017·Journal of the American Academy of Dermatology·Junko TakeshitaJoel M Gelfand
Oct 27, 2017·International Journal of Molecular Sciences·Stephen Chu-Sung Hu, Cheng-Che E Lan
Jan 4, 2018·International Journal of Molecular Sciences·Lluís Puig
Jan 10, 2020·The Journal of Dermatological Treatment·Ali AkhtarAmer Hayat Khan
May 20, 2020·JAMA : the Journal of the American Medical Association·April W Armstrong, Charlotte Read
Mar 13, 2020·Frontiers in Pharmacology·Paolo GisondiCristina Albanesi
Nov 9, 2019·International Journal of Women's Dermatology·Angelica MisitzisGeorge Kroumpouzos
Apr 24, 2021·The Journal of Investigative Dermatology·Di YanWilson Liao
Sep 2, 2021·Current Atherosclerosis Reports·Brittany WeberMichael S Garshick

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